Results 91 to 100 of about 16,792,438 (305)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

OAT BREEDING IN THE KUBAN REGION

Труды по прикладной ботанике, генетике и селекции, 2018
The article presents the history of oat breeding in the Kuban region. Two varieties of spring oats ‘Desant’ and ‘Assol’ have been developed and submitted for the state trials. New varieties are described in detail.
T. E. Kuznetsova, S. A. Levshtanov, N. V. Serkin   +2 more
doaj   +1 more source

Are EU-15 and CEEC agricultural exports in competition? Evidence for 1995-2005 [PDF]

This paper analyses the extent of agricultural competition between EU-15 countries and CEECs during the period 1995–2005 in the light of future EU membership. Finger and Kreinin's index is computed with the BACI database provided by CEPII.
Julie Le Gallo, Marie-Line Duboz
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

DEVELOPMENT OF TOMATO HYBRIDS BASED ON FEMALE PARENTS FORMS WITH FUNCTIONAL MALE STERILITY

Овощи России, 2016
The rate of variability of functional male sterility (ps–2) depending on year of study, genotype and age of the plant is shown. The efficiency of the method of forced ejection of pollen from intact anthers to increase the degree of sterility is shown ...
I. V. Uzun
doaj   +1 more source

The accession migration into construction: a comparative analysis of trade union responses in Denmark, Norway and the UK [PDF]

, 2009
The mobility of labour and services across Europe in the wake of EU enlargement has exceeded predictions and expectations. Since the 2004 accession of Central and Eastern European countries (CEE), the UK alone has received more than 926,000 accession ...
Arnoltz, Jens, Eldring, Line, Fitzgerald, Ian   +2 more
core  

Recombination Line vs. Forbidden Line Abundances in Planetary Nebulae

, 2004
Recombination lines (RLs) of C II, N II, and O II in planetary nebulae (PNs) have been found to give abundances that are much larger in some cases than abundances from collisionally-excited forbidden lines (CELs).
Bohigas J., Cahn J. H., Donald R. Garnett, Flower D. R., Gesicki K., Hyung S., Liu X.-W., Mark Robertson‐Tessi, Mathis J. S., Nussbaumer H., Preite-Martinez A., Preite-Martinez A., Rola C., Storey P. J., Van de Steene G. C., Weinberger R.   +15 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source