Results 101 to 110 of about 9,613,096 (307)
, 1908 Map of the modification in the pierhead and bulkhead line for part of the west shore of Arthur Kill between Piles and Morse Creeks, N.J.
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THE SIMPLIFIED ROTATION METHOD
Journal of Industrial Design and Engineering Graphics, 2019 The simplified rotation method derives from the classic rotation method included in the chapter on descriptive geometry methods. This simplified method eliminates the rotation axis, being a particular case of level or front rotation methods. The omission
Liliana Tocariu
doaj
Competitive Searching for a Line on a Line Arrangement.
, 2018 We discuss the problem of searching for an unknown line on a known or unknown line arrangement by a searcher S, and show that a search strategy exists that finds the line competitively, that is, with detour factor at most a constant when compared to the situation where S has all knowledge. In the case where S knows all lines but not which one is sought,
Quirijn W. Bouts +4 more
openaire +4 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Louise Line Interview, May 5, 1977 [PDF]
, 1977 Louise Line describes growing up in a middle- to upper-class family in the Lake Geneva area of Montana. She discusses her father’s involvement in getting a YMCA built in town and her family’s employment of maids and hired hands.
Line, Louise
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source