Results 231 to 240 of about 9,613,096 (307)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Machine learning quantitative OCT derived fibrosis indicators for corneal haze evaluation. [PDF]

PLoS One
Soubeiran C, Vilbert M, Memmi B, Georgeon C, Borderie V, Chessel A, Plamann K.   +6 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

ASLIF: Accurate Lane-Area Perception Through Adaptive Fusion of Structural Lines and Instance Segmentation. [PDF]

Sensors (Basel)
Liu P, Jia W, Zhu L, Hu Z, Dai W.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Irradiation-Equivalent Injection Test Method for Analyzing HEMP Coupling Effects on Communication Interfaces. [PDF]

Micromachines (Basel)
Sun L, Wu P, Yang L, Tian J, Li Z, He F, Qiu Y.   +6 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Clinical Characteristics, Progression of Disease Within 24 Months (POD24), and Real-World Outcomes of Follicular Lymphoma in Saudi Arabia: A Two-Centre Retrospective Analysis. [PDF]

Cancers (Basel)
Al-Mansour M, Alharbi AS, Sirdar HA, Aljohani A, Gharwa MA, Alsendi HK, Bernawi S, Aga SS, Alsaggaf MA.   +8 more
europepmc   +1 more source

The global burden of female breast cancer attributable to high fasting plasma glucose: A comprehensive analysis of the GBD database from 1990 to 2023. [PDF]

PLoS One
Shi H, Song Z, Chen Y, Liu S, Song Y.
europepmc   +1 more source