Results 91 to 100 of about 10,781,633 (341)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Jixie chuandong, 2014 The gear contact stress is very difficult to calculate and test owing to complexity of gear pairs contact condition by manufacturing error,assembly error,support conditions,deformation of loaded gear pairs,etc.The gear contact can be constituted of line ...
徐恺 +4 more
doaj
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Contact Angle Profiles for Droplets on Omniphilic Surfaces in the Presence of Tangential Forces
Colloids and Interfaces, 2019 In real life, sessile droplets usually have a three-dimensional shape, making it difficult to understand their forced wetting behavior, both from an experimental and a theoretical perspective.
Margaritis Kostoglou +1 more
doaj +1 more source
Lines on complex contact manifolds, II [PDF]
Compositio Mathematica, 2004 Let \(X\) be a projective manifold of dimension \(2n+1\) that carries a contact structure, i.e., there exists a corank one subbundle \(F\) of the tangent bundle such that the O'Neill tensor (which is induced by the Lie brackets) is non-degenerate at every point of \(X\).
openaire +3 more sources
Pinning of a solid--liquid--vapour interface by stripes of obstacles
, 1995 We use a macroscopic Hamiltonian approach to study the pinning of a solid--liquid--vapour contact line on an array of equidistant stripes of obstacles perpendicular to the liquid.
A. Paterson +29 more
core +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Contact line stability of ridges and drops
, 2007 Within the framework of a semi-microscopic interface displacement model we analyze the linear stability of sessile ridges and drops of a non-volatile liquid on a homogeneous, partially wet substrate, for both signs and arbitrary amplitudes of the three ...
A. M. Cazabat +14 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Patterned deposition at moving contact lines [PDF]
Advances in Colloid and Interface Science, 2014 When a simple or complex liquid recedes from a smooth solid substrate it often leaves a homogeneous or structured deposit behind. In the case of a receding non-volatile pure liquid the deposit might be a liquid film or an arrangement of droplets depending on the receding speed of the meniscus and the wetting properties of the system.
openaire +3 more sources