Results 121 to 130 of about 5,599,027 (309)
Trusting the forces of our cell lines
Cells & DevelopmentCells isolated from their native tissues and cultured in vitro face different selection pressures than those cultured in vivo. These pressures induce a profound transformation that reshapes the cell, alters its genome, and transforms the way it senses and generates forces.
Moro López, Marina +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Zhongguo Jianchuan YanjiuObjectiveUnsteady forces generated by pump-jet rotors are a key factor affecting the vibration and noise levels of underwater vehicles. These forces not only induce structural vibrations through coupling between the propeller, shafting, and hull systems,
Wanghao TANG, Junjie XU, Xiuchang HUANG
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
No front line Australia's special forces at war in Afghanistan
, 2017 Australia's foremost investigative journalist goes deep into the heart of our Special Forces long war in AfghanistanChris Masters is Australia's foremost investigative journalist.
Masters, Chris 1985-
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Structural Mechanics of Engineering Constructions and Buildings, 2016 The equationsfor the normal and shear stresses estimation of in structurally not uniform rods are received.These rods possess the variable cross sections and are made from difference modulus materials.
A V Mishchenko
doaj
Airborne command and center. Army Ground Forces study no. 25.
, 2020 A history of the Airborne Command and Center was compiled by various hands during the course of the war. This was completely reworks by the author, Lt. Col. John T.
Historical Section, Army Ground Forces; Ellis, John T., Jr.
core
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source