Results 101 to 110 of about 378,755 (307)

Actuating droplets with electrowetting: Force and dynamics

Droplet
Electrowetting on dielectric (EWOD) allows rapid movement of liquid droplets on a smooth surface, with applications ranging from lab‐on‐chip devices to micro‐actuators. The in‐plane force on a droplet is a key indicator of EWOD performance.
Robert Hennig, Vito Cacucciolo, Herbert Shea   +2 more
doaj   +1 more source

The force-lines field

, 2022
Abstract— To describe gravity in the most precise way and to be able to add it to the Standard Model, furthermore consider it as a force instead of geometry of space-time. The existence of the force-lines is well defined as the field with resistance creating the mass of the particles and gravitational field.
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Outline map of the Pacific /

, 1942
Outline map of the Pacific showing boundaries, status line, and status quo lines.; "File no. 0-42-O.C.E.-19450 Pacific"; "For use by the Armed Forces only - not for sale or distribution"; Also available online http://nla.gov.au/nla.map ...
United States. Army. Forces in Australia. Office of the Chief Engineer, cartographer.
core  

The development of magmatism along the Cameroon Volcanic Line: evidence from seismicity and seismic anisotropy [PDF]

, 2014
The Cameroon Volcanic Line (CVL) straddles the continent-ocean boundary in West Africa but exhibits no clear age progression. This renders it difficult to explain by traditional plume/plate motion hypotheses; thus, there remains no consensus on the ...
R. J. Gallacher, J. Keane, Keir, D, I. D. Bastow, Chambers, EL, Keane, J, Chambers, E.L., E. L. Chambers, De Plaen, RSM, Keane, J., Keir, D., D. Keir, Bastow, ID, R. S. M. De Plaen, De Plaen, R.S.M., Gallacher, RJ, Keir, Derek Boswell, Bastow, I.D., Gallacher, R.J.   +18 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

When contact lines remember: Surface charge and the evolving interaction with defects

Droplet
The motion of contact line plays a crucial role in both natural phenomena and industrial processes. While it is well known that surface defects influence contact line dynamics, we demonstrate that their impact depends not only on geometry, size, and ...
Yaolei Xiang, Benedikt Straub, Diego Cortes, Hans‐Jürgen Butt, Kaloian Koynov   +4 more
doaj   +1 more source