Results 91 to 100 of about 378,755 (307)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Statyka Rozgałęzionych Przestrzennych Rurociągów Samokompensacyjnych

open access: yesEngineering Transactions, 1963
The state of stress and displacement in a spatial branched pipe line is analysed. Next, a method is proposed for determining the forces and moments due to the influence of temperature and continuous load.
C. Woźniak
doaj  

On Lines of Magnetic Force [PDF]

open access: yesProceedings of the Edinburgh Mathematical Society, 1891
In my laboratory we make great use of the method of tracing lines of force described in Glazebrook and Shaw's Practical Physics. The field is modified in various ways; for instance, the fixed magnets are sometimes placed so as to somewhat resemble in their disposition the field magnets of a dynamo: sometimes a circular piece of soft iron is placed in ...
openaire   +1 more source

WAVE FORCES ON SUBMERGED PIPE LINES

open access: yesCoastal Engineering Proceedings, 1972
This is a presentation of the analyses of data obtained from a laboratory investigation of horizontal forces produced by oscillatory waves on submerged pipes. The research program was planned to help solve design problems for pipe lines located on or below the bottom in the oceans or the Great Lakes.
Ernest F. Brater, Roger Wallace
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Trends of Battle Line Formation

open access: yesBuletinul Ştiinţific al Academiei Trupelor de Uscat, 2020
This article presents basic concepts regarding the establishment of the battle lines depending on the level of the warfare. Thus, at the operative level within the operations of the task force level division (brigades) will be used principles that ...
Ciubara Iurii
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Strength Analysis of Preliminary Insulated Self-Compensating Power-and-Heat Generation Pipe Line

open access: yesИзвестия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2004
The paper contains strength analysis of preliminary insulated self-compensating power-and- heat pipe line under the action of forces initiated by temperature difference.
V. A. Sednin   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Evaluating the Validity of Quasi-Static Analysis for Prediction of Vessel Mooring Line Forces

open access: yesInternational Journal of Maritime Technology, 2013
Quasi-Static analysis of moored vessels is vastly used for engineering designs, as a substitute to the numerical simulation of dynamic mooring analysis. Yet, the level of validity of the results of quasi-static analysis is a matter of discussion.
Ahmad Shanehsazzadeh
doaj  

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