Results 111 to 120 of about 5,599,027 (309)
Laplace equation and Faraday's lines of force
Water Resources Research, 2008 Boundary‐value problems involve two dependent variables: a potential function and a stream function. They can be approached in two mutually independent ways. The first, introduced by Laplace, involves spatial gradients at a point. Inspired by Faraday, Maxwell introduced the other, visualizing the flow domain as a collection of flow tubes and ...
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
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Taut-line buzzers with periodic forcing
Physical Review AppliedThe time-dependent forcing and work per cycle required to drive sinusoidal spinning of a taut-line buzzer is analytically derived, both on and off resonance, from the nonlinear equation of motion. To test predictions, a model experimental system is constructed and characterized in terms of contraction versus twist angle and damped oscillations.
Jesse M. Hanlan, Douglas J. Durian
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, 1981 Square wood and metal plaque with the badge of the Canadian Armed Forces. The plaque reads, To His Excellency Kenneth M. Curtis with Best Wishes of the Chief of Defence Staff and the Canadian Armed Forces Jan, 1981 .https://digitalcommons.usm.maine.edu ...
Canadian Armed Forces
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
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Forced to line up for perfect order
Nature Materials, 2019 Physical confinement and magnetic fields are used to align organic molecules that self-assemble into large-size single crystals with perfect positional order.
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Configurational Forces on Elastic Line Singularities
, 2018 Configurational forces acting on two-dimensional (2D) elastic line singularities are evaluated by path-independent J-, M-, and L-integrals in the framework of plane strain linear elasticity. The elastic line singularities considered in this study are the
Youjung Seo +3 more
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
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