Results 41 to 50 of about 2,098,248 (309)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Full non-LTE multi-level radiative transfer

open access: yesAstronomy & Astrophysics
The so-called full non-local thermodynamic equilibrium (FNLTE) radiative transfer problem allows us to take into account not only deviations of the radiation field from the Planck function but also deviations in the densities and the velocity ...
Lagache T., Sampoorna M., Paletou F.
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Measuring the star formation rate density from CNOC2 [PDF]

open access: yes, 2006
This thesis charts the evolution of the Universal Star Formation Rate Density (SFRD) across the redshift range 0.2 < z < 0.6, using the 2nd Canadian Network for Observational Cosmology Survey (CN0C2).
Whitaker, Richard James
core  

Monitoring the plasmapause using geomagnetic field line resonances [PDF]

open access: yes, 2004
This paper discusses the use of ground magnetometer data to derive plasma mass density profiles of the dayside plasmapause region with spatial and temporal resolution in the range 0.15-0.4 R-E and 20-60 min.
Menk, F.W.   +5 more
core   +1 more source

Analysis of wt1a reporter line expression levels during proepicardium formation in the zebrafish. [PDF]

open access: yes, 2020
The epicardium is the outer mesothelial layer of the heart. It covers the myocardium and plays important roles in both heart development and regeneration.
Galardi Castilla, María   +5 more
core   +1 more source

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