Results 51 to 60 of about 2,098,248 (309)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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A Low-mass line-rich Core Found in Massive Star-forming Region IRAS 16351-4722
The Astrophysical Journal, 2023 We present Atacama Large Millimeter/submillimeter Array subarcsecond-resolution observations of both continuum and molecular lines at 345 GHz toward the massive star-forming region IRAS 16351-4722 (hereafter I16351).
Meizhu Liu +12 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation. [PDF]
PLoS Genetics, 2015 The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits retroviruses, DNA viruses and long interspersed element 1 (LINE-1). Given that in dividing cells, SAMHD1 loses its antiviral function yet still potently restricts LINE-1, we propose that,
Siqi Hu +10 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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Unravelling the complex structure of the Fe II emission region in Type 1 active galactic nuclei
Astronomy & AstrophysicsAims. Using a large sample of Type 1 active galactic nucleus spectra, we investigated the complex structure of the Fe II emission region with the aim of understanding the atomic processes responsible for the enhancement of the Fe II emission. We explored
Kovačević-Dojčinović Jelena +2 more
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The Astrophysical Journal, 2023 We model the early stages of planet formation in the solar system, including continual planetesimal formation, and planetesimal and pebble accretion onto planetary embryos in an evolving disk driven by a disk wind.
John Chambers
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Free energy analysis of membrane pore formation process in the presence of multiple melittin peptides [PDF]
, 2019 Understanding the molecular mechanism underlying pore formation in lipid membranes by antimicrobial peptides is of great importance in biological sciences as well as in drug design applications. Melittin has been widely studied as a pore forming peptide,
Shinoda, Wataru +2 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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