Results 71 to 80 of about 10,056,652 (288)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

The coronal line region of active galactic nuclei

open access: yesFrontiers in Astronomy and Space Sciences
Forbidden coronal lines has traditionally called the attention due to the high-energy photons required for their production (IP >100 eV, where IP is the ionisation potential of the transitions that originate the line).
Alberto Rodríguez-Ardila   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Tasmanian main line railway [cartographic material].

open access: yes, 1880
Map showing the main railway line from Hobart to Launceston in red, the Mersey, Deloraine, Launceston and Western Railway in black and the projected line from Bridgewater in a broken red line.; Australian Encyclopedia, 6th ed., v. 7, p.

core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Vehicle Formation Scheme for Wuxi Metro Line 5

open access: yesChengshi guidao jiaotong yanjiu
Objective To somewhat address the issues of low passenger load factor, high operating cost, and excessive reliance on government subsidies in medium-sized urban rail transit network, taking Wuxi Metro Line 5 as example, a formation scheme of new line ...
LU Jie, FAN Yong, FENG Liyuan
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Line and V-Shape Formation Based Distributed Processing for Robotic Swarms

open access: yesSensors, 2018
Efficient distributed processing is vital for collaborative searching tasks of robotic swarm systems. Typically, those systems are decentralized, and the members have only limited communication and processing capacities. What is illustrated in this paper
Jian Yang, Xin Wang, Peter Bauer
doaj   +1 more source

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