Results 91 to 100 of about 10,056,652 (288)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Line Formation in Moving Atmospheres [PDF]
International Astronomical Union Colloquium, 1970 AbstractWe discuss an integral equation method that permits the calculation of the line source functions and of the emergent profiles in finite and semiinfinite atmospheres with macroscopic motion normal to the surface. Solutions are presented for a semiinfinite atmosphere with a temperature rise in the outward direction and with a flow that decays ...
openaire +1 more source
LSD: a Line Segment Detector [PDF]
, 2012 LSD is a linear-time Line Segment Detector giving subpixel accurate results. It is designed to work on any digital image without parameter tuning. It controls its own number of false detections: On average, one false alarms is allowed per image.
Randall, Gregory +7 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Secteur de formation 19 : santé
, 2008 Titre de l'écran-titre (visionné le 21 août 2008)"Secteur de formation 19 ...
Fons, Jean-Pierre +4 more
core +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Astronomy & AstrophysicsContext. Many complex organic molecules (COMs) in star-forming regions are believed to form on dust grains. We thus expect both the reduced metallicity and dust-to-gas ratio in the outer Galaxy to have an impact on the chemical composition of these ...
Wang Youxin +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
AND ASTROPHYSICS Line formation in solar granulation
, 2000 . Realistic ab-initio 3D, radiative-hydrodynamical convection simulations of the solar granulation have been applied to Fe i and Fe ii line formation. In contrast to classical analyses based on hydrostatic 1D model atmospheres the procedure contains no ...
R. F. Stein +5 more
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