Mechanism of Kin-Discriminatory Demarcation Line Formation between Colonies of Swarming Bacteria. [PDF]
Biophys J, 2017 Patra P +3 more
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Benefit of Contact Force Sensing Catheter Technology for Successful Left Atrial Anterior Line Formation: A Prospective Randomized Trial. [PDF]
Biomed Res Int, 2018 Fichtner S +13 more
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement. [PDF]
Nat Cell Biol, 2014 Kutscheidt S +6 more
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Detailed Study of Stars and Gas in a z = 8.3 Massive Merger with Extreme Dust Conditions
The Astrophysical Journal LettersWe present galaxy MACS0416-Y1 at z _spec = 8.312 as observed by the CAnadian NIRISS Unbiased Cluster Survey. MACS0416-Y1 has been shown to have extreme dust properties; thus, we study the physical properties and star formation histories of its resolved ...
Anishya Harshan +17 more
doaj +1 more source
Reinforcing the LINC complex connection to actin filaments: the role of FHOD1 in TAN line formation and nuclear movement. [PDF]
Cell Cycle, 2015 Antoku S +4 more
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Doubly uniparental inheritance of mitochondria as a model system for studying germ line formation. [PDF]
PLoS One, 2011 Milani L +3 more
europepmc +1 more source