Results 131 to 140 of about 2,098,248 (309)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Non-LTE line formation for N

, 2001
A comprehensive model atom for non-LTE line formation calculations for neutral and singly-ionized nitrogen is presented. Highly accurate radiative and collisional atomic data are incorporated, recently determined for astrophysical and fusion research ...
N. Przybilla, K. Butler
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

ODIN: Improved Narrowband Lyα Emitter Selection Techniques for z = 2.4, 3.1, and 4.5

The Astrophysical Journal
Lyman-alpha-emitting galaxies (LAEs) are typically young, low-mass, star-forming galaxies with little extinction from interstellar dust. Their low dust attenuation allows their Ly α emission to shine brightly in spectroscopic and photometric observations,
Nicole M. Firestone, Eric Gawiser, Vandana Ramakrishnan, Kyoung-Soo Lee, Francisco Valdes, Changbom Park, Yujin Yang, Robin Ciardullo, María Celeste Artale, Barbara Benda, Adam Broussard, Lana Eid, Rameen Farooq, Caryl Gronwall, Lucia Guaita, Stephen Gwyn, Ho Seong Hwang, Sang Hyeok Im, Woong-Seob Jeong, Shreya Karthikeyan, Dustin Lang, Byeongha Moon, Nelson Padilla, Marcin Sawicki, Eunsuk Seo, Akriti Singh, Hyunmi Song, Paulina Troncoso Iribarren   +27 more
doaj   +1 more source

Swarm Robotics: Parallelized Line Formation

, 2008
Swarm robotics is a fast growing field, where robots come together to collectively tackle tasks difficult to achieve otherwise. Physical connection is a common requirement, where a particular shape is desired. A line is one of the more common shapes, and
Feldman, Alexander
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The COS-Holes Survey: Connecting Galaxy Black Hole Mass with the State of the CGM

The Astrophysical Journal
We present an analysis of Hubble Space Telescope COS/G160M observations of C IV in the inner circumgalactic medium (CGM) of a novel sample of eight z ∼ 0, L ≈ L ^⋆ galaxies, paired with UV-bright QSOs at impact parameters ( R _proj ) between 25 and 130 ...
Samantha L. Garza, Jessica K. Werk, Benjamin D. Oppenheimer, Kirill Tchernyshyov, N. Nicole Sanchez, Yakov Faerman, Kate H. R. Rubin, Misty C. Bentz, Jonathan J. Davies, Joseph N. Burchett, Robert A. Crain, J. Xavier Prochaska   +11 more
doaj   +1 more source

Molecular emission line formation in prestellar cores

, 2008
We investigate general aspects of molecular line formation under conditions typical of prestellar cores. Focusing on simple linear molecules, we study the formation of their rotational lines with radiative transfer simulations.
Pavlyuchenkov, Ya, Launhardt, R., Shustov, B., Wiebe, D., Henning, Th, Semenov, D.   +5 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source