Results 31 to 40 of about 263,441 (263)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Improved Neural Networks Based on Mutual Information via Information Geometry
Algorithms, 2019 This paper presents a new algorithm based on the theory of mutual information and information geometry. This algorithm places emphasis on adaptive mutual information estimation and maximum likelihood estimation.
Meng Wang +5 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
A Clifford Algebraic Approach to Line Geometry [PDF]
Advances in Applied Clifford Algebras, 2014 In this paper we combine methods from projective geometry, Klein's model, and Clifford algebra. We develop a Clifford algebra whose Pin group is a double cover of the group of regular projective transformations. The Clifford algebra we use is constructed as homogeneous model for the five-dimensional real projective space $P^5(\mathbb{R})$ where Klein's
openaire +2 more sources
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Pattern Formation and Tropical Geometry
Frontiers in Physics, 2020 Sandpile models exhibit fascinating pattern structures: patches, characterized by quadratic functions, and line-shaped patterns (also called solitons, webs, or linear defects).
Nikita Kalinin, Nikita Kalinin
doaj +1 more source
Energy Conversion and Management: X, 2023 We present a speed line calculation model using physics-based surge point identification. When using surrogate model-based design of experiment (DOE) techniques, the large number of computations demands an automated, unsupervised process to calculate the
Yannick Lattner +2 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source