Results 41 to 50 of about 5,172,925 (243)
JOHME: Journal of Holistic Mathematics Education, 2022 The studies on the worked-out examples teaching approach (WOETA) have been investigated globally and in South Africa, showing gains in learners' performance. This study reports on the Euclidean geometry short learning programme (EGSLP), which used worked-
Msebenzi Rabaza, Joleen Hamilton
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
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Improved Neural Networks Based on Mutual Information via Information Geometry
Algorithms, 2019 This paper presents a new algorithm based on the theory of mutual information and information geometry. This algorithm places emphasis on adaptive mutual information estimation and maximum likelihood estimation.
Meng Wang +5 more
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A Clifford Algebraic Approach to Line Geometry [PDF]
Advances in Applied Clifford Algebras, 2014 In this paper we combine methods from projective geometry, Klein's model, and Clifford algebra. We develop a Clifford algebra whose Pin group is a double cover of the group of regular projective transformations. The Clifford algebra we use is constructed as homogeneous model for the five-dimensional real projective space $P^5(\mathbb{R})$ where Klein's
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Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
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SMARANDACHE ANTI-GEOMETRY [PDF]
, 2004 This is an experimental geometry. All Hilbert's 20 axioms of the Euclidean GGeometry are denied in this vanguardist geometry of the real chaos: What is even more intriguing?
Bencze, Mihaly, Chimienti, Sandy P.
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Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
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USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Energy Conversion and Management: X, 2023 We present a speed line calculation model using physics-based surge point identification. When using surrogate model-based design of experiment (DOE) techniques, the large number of computations demands an automated, unsupervised process to calculate the
Yannick Lattner +2 more
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