Results 41 to 50 of about 263,441 (263)

Correspondences between convex geometry and complex geometry [PDF]

Épijournal de Géométrie Algébrique, 2017
We present several analogies between convex geometry and the theory of holomorphic line bundles on smooth projective varieties or K\"ahler manifolds. We study the relation between positive products and mixed volumes.
Brian Lehmann, Jian Xiao
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

LIVING THE GEOMETRY: DIALOGUES BETWEEN THE LINE AND THE CURVE

EGA, 2012
The geometry has been one of the key tools used by twentieth century architects. If the research is delimitated by relationship between two of the most important elements of it, the straight line and the curve by mean of the study of three paradigmatic ...
Juan Pedro Sanz Alarcón, Pedro García Martínez, Miguel Centellas Soler   +2 more
doaj   +1 more source

On the continuity of Weil-Petersson volumes of the moduli space weighted points on the projective line

Complex Manifolds, 2022
In this work we show that the Weil-Petersson volume (which coincides with the CM degree) in the case of weighted points in the projective line is continuous when approaching the Calabi-Yau geometry from the Fano geometry. More specifically, the CM volume
Tambasco Salvatore
doaj   +1 more source

Near-optimal algorithms for point-line fitting problems

Journal of Computational Geometry, 2022
We study the {\sc Rich Lines} problem, which is a fundamental point-line fitting problem in computational geometry. In this problem, the input is a set $S$ of points in the plane, and the goal is to compute the set of all lines that each covers at least
Jianer Chen, Qin Huang, Iyad Kanj, Ge Xia   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Comparison of Single-Site Ionospheric Delays Derived from Geometry-Free and Geometry-Based Approaches with an Analysis of Orbit and Clock Error Effects

Atmosphere, 2021
The reparameterization of the geometry-free and geometry-based approaches to derive single-site ionospheric delays using Global Navigation Satellite System (GNSS) measurements is described.
Sijing Liu, Qile Zhao, Gang Chen, Zhigang Hu, Nengfang Chao   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Nonintrusive overhead‐line current detection using a vertical magnetic‐field sensor array

IET Generation, Transmission & Distribution, 2023
With the growing infrastructure for overhead lines, the demand for overhead‐line condition‐monitoring technologies has become increasingly urgent. Traditional current transformers used to measure three‐phase currents are bulky and difficult to install ...
Kun‐Long Chen, Chia‐Lun Wang, Rui‐Xiang Chen   +2 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source