Results 41 to 50 of about 248,414 (310)
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Energy Conversion and Management: X, 2023 We present a speed line calculation model using physics-based surge point identification. When using surrogate model-based design of experiment (DOE) techniques, the large number of computations demands an automated, unsupervised process to calculate the
Yannick Lattner +2 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Pattern Formation and Tropical Geometry
Frontiers in Physics, 2020 Sandpile models exhibit fascinating pattern structures: patches, characterized by quadratic functions, and line-shaped patterns (also called solitons, webs, or linear defects).
Nikita Kalinin, Nikita Kalinin
doaj +1 more source
Complex Manifolds, 2022 In this work we show that the Weil-Petersson volume (which coincides with the CM degree) in the case of weighted points in the projective line is continuous when approaching the Calabi-Yau geometry from the Fano geometry. More specifically, the CM volume
Tambasco Salvatore
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Correspondences between convex geometry and complex geometry [PDF]
Épijournal de Géométrie Algébrique, 2017 We present several analogies between convex geometry and the theory of holomorphic line bundles on smooth projective varieties or K\"ahler manifolds. We study the relation between positive products and mixed volumes.
Brian Lehmann, Jian Xiao
doaj +1 more source
Absolute Embeddings of Point–Line Geometries
Journal of Algebra, 2001 The paper concerns the existence of absolute embeddings \(e\) of point-line geometries \(\Gamma=({\mathcal P},{\mathcal L})\), that is, any embedding of \(\Gamma\) in some projective space can be derived from \(e\) by projecting onto suitable quotient spaces.
Kasikova, A, Shult, E
openaire +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source