Results 41 to 50 of about 252,055 (264)

LIVING THE GEOMETRY: DIALOGUES BETWEEN THE LINE AND THE CURVE

EGA, 2012
The geometry has been one of the key tools used by twentieth century architects. If the research is delimitated by relationship between two of the most important elements of it, the straight line and the curve by mean of the study of three paradigmatic ...
Juan Pedro Sanz Alarcón, Pedro García Martínez, Miguel Centellas Soler   +2 more
doaj   +1 more source

Pattern Formation and Tropical Geometry

Frontiers in Physics, 2020
Sandpile models exhibit fascinating pattern structures: patches, characterized by quadratic functions, and line-shaped patterns (also called solitons, webs, or linear defects).
Nikita Kalinin, Nikita Kalinin
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Nonintrusive overhead‐line current detection using a vertical magnetic‐field sensor array

IET Generation, Transmission & Distribution, 2023
With the growing infrastructure for overhead lines, the demand for overhead‐line condition‐monitoring technologies has become increasingly urgent. Traditional current transformers used to measure three‐phase currents are bulky and difficult to install ...
Kun‐Long Chen, Chia‐Lun Wang, Rui‐Xiang Chen   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Probabilistic Geometry Based on the Fuzzy Playfair Axiom

Foundations
A probabilistic version of geometry is introduced. The fifth postulate of Euclid (Playfair’s axiom) is adopted in the following probabilistic form: consider a line and a point not on the line—there is exactly one line through the point with probability P,
Edward Bormashenko
doaj   +1 more source

A Clifford Algebraic Approach to Line Geometry [PDF]

Advances in Applied Clifford Algebras, 2014
In this paper we combine methods from projective geometry, Klein's model, and Clifford algebra. We develop a Clifford algebra whose Pin group is a double cover of the group of regular projective transformations. The Clifford algebra we use is constructed as homogeneous model for the five-dimensional real projective space $P^5(\mathbb{R})$ where Klein's
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

ESTIMATING TORSION OF DIGITAL CURVES USING 3D IMAGE ANALYSIS

Image Analysis and Stereology, 2016
Curvature and torsion of three-dimensional curves are important quantities in fields like material science or biomedical engineering. Torsion has an exact definition in the continuous domain.
Christoph Blankenburg, Christian Daul, Joachim Ohser   +2 more
doaj   +1 more source