Results 61 to 70 of about 248,414 (310)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

ESTIMATING TORSION OF DIGITAL CURVES USING 3D IMAGE ANALYSIS

open access: yesImage Analysis and Stereology, 2016
Curvature and torsion of three-dimensional curves are important quantities in fields like material science or biomedical engineering. Torsion has an exact definition in the continuous domain.
Christoph Blankenburg   +2 more
doaj   +1 more source

BUBBLING GEOMETRIES FOR HALF-BPS WILSON LINES [PDF]

open access: yesInternational Journal of Modern Physics A, 2007
We consider the supergravity backgrounds that correspond to supersymmetric Wilson line operators in the context of AdS/CFT correspondence. We study the gravitino and dilatino conditions of the IIB supergravity under the appropriate ansatz, and obtain some necessary conditions for a supergravity background that preserves the same symmetry as the ...
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Exploration of mathematical concepts in Batik Truntum Surakarta

open access: yesInfinity
This research investigates the mathematical concepts embedded within Batik Truntum motifs, including geometry, analysis, arithmetic, and algebra. Employing a qualitative methodology with an ethnographic approach, the study addresses four critical ...
Adi Nurcahyo   +3 more
doaj   +1 more source

Applications of Conformal Geometric Algebra to Transmission Line Theory

open access: yesIEEE Access, 2017
In this paper, we present the application of a projective geometry tool known as conformal geometric algebra (CGA) to transmission line theory. Explicit relationships between the Smith Chart, Riemann Sphere, and CGA are developed to illustrate the ...
Alex Arsenovic
doaj   +1 more source

Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu   +16 more
wiley   +1 more source

Increased Blood Levels of NfL, GFAP, and Placental Growth Factor After Radiotherapy to the Brain

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this study, we analyzed biomarkers of neuronal, glial, and vascular injury in longitudinal paired samples of blood and cerebrospinal fluid after prophylactic cranial irradiation in patients with small cell lung cancer. Neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAP) increased in serum and cerebrospinal ...
Erik Fernström   +5 more
wiley   +1 more source

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