Results 121 to 130 of about 168,150,866 (290)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Single-valuedness of the AdS Veneziano amplitude

Journal of High Energy Physics
We consider the Veneziano amplitude for the scattering of gluons in type IIB string theory on AdS 5 × S 5/ℤ 2 in the presence of D7 branes. On general grounds curvature corrections around flat space can be thought of as arising from the extra insertion ...
Luis F. Alday, Tobias Hansen
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Maximal Graphs and Spacelike Mean Curvature Flows in Semi-Euclidean Spaces [PDF]

, 2011
Two main results are proved. The first is for the maximal graph system in semi-Euclidean spaces. Existence of smooth solutions to the Dirichlet problem is proved, under certain assumptions on the boundary data.
THORPE, BENJAMIN,STUART, Thorpe, Benjamin Stuart   +1 more
core  

Algebraic theory of affine curvature tensors [PDF]

, 2006
summary:We use curvature decompositions to construct generating sets for the space of algebraic curvature tensors and for the space of tensors with the same symmetries as those of a torsion free, Ricci symmetric connection; the latter naturally appear in
Nikčević, S., Gilkey, P., Simon, U., Blažić, N.   +3 more
core   +1 more source

Craniocervical Posture and Cervical Curvature Variations in Adult Females with Different Vertical Facial Patterns: A Cross-Sectional Study

Applied Sciences
This study aimed to determine whether there are relationships between vertical facial patterns, cervical posture, and cervical curvature types. Ninety-two adult females with skeletal Class I relationships were retrospectively analyzed and divided into ...
Jeongeun Chang, Sun-Hyung Park, Jae Hyun Park, Sanghee Lee, Hyung-Seog Yu, Kee-Joon Lee, Chooryung J. Chung, Kyung-Ho Kim   +7 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Curvature‐driven Multi‐stream Network for Feature‐preserving Mesh Denoising

Mesh denoising is a fundamental yet challenging task. Most of the existing data‐driven methods only consider the zero‐order information (vertex location) and first‐order information (face normal).
Zhao, Zhibo, Tang, Wenming, Gong, Yuanhao   +2 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source