Results 91 to 100 of about 984,465 (267)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Broad-Line Profile Variability [PDF]

International Astronomical Union Colloquium, 1997
AbstractMany years of monitoring a sample of 10 AGNs with a median sampling rate of about one spectrum per week yields strong evidence that broad-line profile variations are not induced by reverberation effects, but rather signify real changes in the structure of the continuum-source and broad-line region complex, contrary to line flux variations ...
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Contribution of the Electron Scattering Process to the Broad Hα Wings

Open Astronomy, 2012
We modeled the extended wings of the OVI 1032, 1038 Å resonance lines and He II 1640 Å emission line in the spectra of Z And, AG Dra and V1016 Cyg by the electron scattering process.
Sekeráš M., Skopal A.
doaj   +1 more source

Stark broadening of N II spectral lines [PDF]

Serbian Astronomical Journal
The Stark broadening parameters, widths, and shifts, for spectral lines within the 45 N II multiplets, were calculated for collisions with electrons, protons and helium ions, by using the semiclassical perturbation method. The obtained data were
Dimitrijević Milan S., Christova Magdalena D., Sahal-Bréchot Sylvie   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Unravelling the complex structure of the Fe II emission region in Type 1 active galactic nuclei

Astronomy & Astrophysics
Aims. Using a large sample of Type 1 active galactic nucleus spectra, we investigated the complex structure of the Fe II emission region with the aim of understanding the atomic processes responsible for the enhancement of the Fe II emission. We explored
Kovačević-Dojčinović Jelena, Dojčinović Ivan, Popović Luka Č.   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Diffraction line profiles of spherical hollow nanocrystals

Nanomaterials and Nanotechnology, 2019
An analytical expression of diffraction line profiles of spherical hollow nanocrystals (NCs) is derived. The particular features of the profile lines, enhanced peak tail intensity, are analyzed and discussed as a function of the NC size parameters (outer
Emiliano Burresi, Leander Tapfer
doaj   +1 more source