Results 91 to 100 of about 6,236,563 (298)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Data-driven analysis of neutron diffraction line profiles: application to plastically deformed Ta. [PDF]

Sci Rep, 2022
Tallman AE, Pokharel R, Bamney D, Spearot DE, Clausen B, Lebensohn RA, Brown D, Capolungo L.   +7 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Profile line accuracy in cephalometric radiographs

American Journal of Orthodontics and Dentofacial Orthopedics
Introduction This study investigates the accuracy of facial soft-tissue profile lines in lateral cephalometric radiographs by comparing them to true profile lines derived from 3-dimensional photographs.Methods This prospective methodological study was performed on preexisting records of 100 orthodontic patients.
Marie-Laure Arn, Jasmina Opacic, Georgios Kanavakis, Demetrios Halazonetis, Nikolaos Gkantidis   +4 more
openaire   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Tasmanian main line railway [cartographic material].

, 1880
Map showing the main railway line from Hobart to Launceston in red, the Mersey, Deloraine, Launceston and Western Railway in black and the projected line from Bridgewater in a broken red line.; Australian Encyclopedia, 6th ed., v. 7, p.

core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Emission line profiles and X-ray observations of broad and narrow line Seyfert 1 galaxies

, 2011
Narrow Line Seyfert 1 galaxies represent a distinct category in the larger family of Type 1 Active Galactic Nuclei. The occurrence of emission line profiles not broader than 2000 km/s, combined with luminosity estimates comparable to those of their broad
CIROI, STEFANO, LA MURA, GIOVANNI, RAFANELLI, PIERO, CRACCO, VALENTINA, L. Popovic, D. Ilic   +5 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source