Results 101 to 110 of about 8,079,770 (310)

Towards a UML Profile for Software Product Lines [PDF]

open access: yes, 2004
This paper proposes a UML profile for software product lines. This profile includes stereotypes, tagged values, and structural constraints and it makes possible to define PL models with variabilities. Product derivation consists in generating product models from PL models.
Ziadi, Tewfik   +2 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

DOUBLETS AND DOUBLE PEAKS: LATE-TIME [O i] λλ6300, 6364 LINE PROFILES OF STRIPPED-ENVELOPE, CORE-COLLAPSE SUPERNOVAE [PDF]

open access: yes, 2009
We present optical spectra of SN 2007gr, SN 2007rz, SN 2007uy, SN 2008ax, and SN 2008bo obtained in the nebular phase when line profiles can lead to information about the velocity distribution of the exploded cores. We compare these to 13 other published
D. Milisavljevic   +4 more
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Long-term variability of the optical spectra of NGC 4151 - II. Evolution of the broad Hα and Hβ emission-line profiles [PDF]

open access: yes, 2009
Aims. We present the results of a long-term monitoring (11 years, between 1996 and 2006) of Hα and Hβ line variations of the active galactic nucleus of NGC 4151. Methods. High quality spectra (S /N > 50 and R ≈ 8A ) of Hα and Hβ were investigated. During
A. Shapovalova   +9 more
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

THE EVOLUTION OF MOLECULAR LINE PROFILES INDUCED BY THE PROPAGATION OF C-SHOCK WAVES [PDF]

open access: yes, 2009
We present the first results of the expected variations of the molecular line emission arising from material recently affected by C-shocks (shock precursors).
I. Jímenez-Serra   +4 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Data-driven analysis of neutron diffraction line profiles: application to plastically deformed Ta. [PDF]

open access: yesSci Rep, 2022
Tallman AE   +7 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy