Results 251 to 260 of about 8,079,770 (310)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Study of prompt gamma and neutron emission for real-time range verification in proton and carbon-ion therapy. [PDF]

Med Phys
Bellotti ES, Mazzucconi D, Bortot D, Pola A, Fiorini C, Urban K, Agosteo S.   +6 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release. [PDF]

Elife
Emperador-Melero J, Del Signore SJ, De León González KM, Kaeser PS, Rodal AA.   +4 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Distinguishing near- versus off-critical phase behaviors of intrinsically disordered proteins. [PDF]

Rep Prog Phys
Mitra G, Ghosh S, Ruff KM, Zhang R, Chauhan G, Pappu RV.   +5 more
europepmc   +1 more source

Spectral Line Profiles in Plasmas

Journal of the Spectroscopical Society of Japan, 1968
openaire   +2 more sources

Position-dependent feedback drives scaling and robustness of morphogen gradients. [PDF]

Proc Natl Acad Sci U S A
Mosby LS, Hadjivasiliou Z.
europepmc   +1 more source

Modeling Highlights the Challenge of Achieving and Maintaining Hepatitis C Virus Micro-Elimination Among People Who Inject Drugs. [PDF]

Open Forum Infect Dis
Tatara E, Shekhtman L, Collier N, Cotler SJ, Mackesy-Amiti ME, Boodram B, Dahari H, Major M, Ozik J.   +8 more
europepmc   +1 more source

Retinal arteriovenous crossings as spatiotemporal stress fields: a quantitative Doppler OCT flowmetry study. [PDF]

Sci Rep
Akiba M, Minamide K, Najac MJ, Duran LM, Haq A, Chui TYP, Rosen RB.   +6 more
europepmc   +1 more source