Results 61 to 70 of about 6,236,563 (298)
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad +9 more
wiley +1 more source
Iron abundance determination for the solar-like stars HR 4345 and HR 6573 [PDF]
Using the BLACKWELL software package written by R.O. Gray, the iron abundance of the solar-like stars HR 4345 and HR 6573 has been determined. The method is based on determination of the minimum dispersion (or the region of least confusion) of the iron ...
Vince Oliver I., Vince Ištvan I.
doaj +1 more source
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
On the modifications of oscillator strengths and damping constants of Fe I spectral lines from 500 nm to 510 nm [PDF]
We modified oscillator strengths and enhancement factors of van der Waals damping constants for 84 moderately strong and weak neutral iron spectral lines between 500 nm and 510 nm, by fitting the solar synthetic spectrum to the observed one.
Čeki A., Latković O., Vince Ištvan I.
doaj +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hα line variations of 8 B-emission (Be) stars are presented. Stars that are listed in the Bright Star Catalogue were observed in 2009 at the Bosscha Observatory, Lembang, Indonesia. It was found that 4 stars showed phase changing from Be double-peaked to
Aprilia Aprilia +7 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Long-term variability of the optical spectra of NGC4151. II. Evolution of the broad Hα and Hβ emission-line profiles. [PDF]
Aims. We present the results of a long-term monitoring (11 years, between 1996 and 2006) of Hα and Hβ line variations of the active galactic nucleus of NGC4151. Methods. High quality spectra (S/N > 50 and R ≈ 8 Å) of Hα and Hβ were investigated.
VAHRAM CHAVUSHYAN +1 more
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