Results 111 to 120 of about 820,651 (313)

Were people imitating others or exercising rational choice in on-line searches for 'swine flu'? [PDF]

, 2009
R. Alexander Bentley, Paul Ormerod
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Image stitching algorithm based on two-stage optimal seam line search

Journal of King Saud University: Computer and Information Sciences
Traditional feature matching algorithms often struggle with poor performance in scenarios involving local detail deformations under varying perspectives.
Guijin Han, Yuanzheng Zhang, Mengchun Zhou   +2 more
doaj   +1 more source

A Sensitive Line Search in Circumstellar Envelopes [PDF]

, 1988
Nguyen-Q-Rieu, Shuji Deguchi, Hideyuki Izumiura, Norio Kaifu, Masatoshi Ohishi, Hiroshi Suzuki, Nobuharu Ukita   +6 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Data and performance of an active-set truncated Newton method with non-monotone line search for bound-constrained optimization. [PDF]

Data Brief, 2018
Cristofari A, De Santis M, Lucidi S, Rinaldi F.   +3 more
europepmc   +1 more source

Application of Memetic Algorithms in the Search-based Product Line Architecture Design: An Exploratory Study

, 2017
João Choma Neto, Thelma Elita Colanzi, Aline Maria Malachini Miotto Amaral   +2 more
openalex   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

New hybrid conjugate gradient methods with the generalized Wolfe line search. [PDF]

Springerplus, 2016
Xu X, Kong FY.
europepmc   +1 more source