Results 91 to 100 of about 7,898,408 (287)
Euphemisms and dysphemism: in search of a boundary line
Círculo de Lingüística Aplicada a la Comunicación, 2011 Straightforward remarks may sometimes be regarded as either an offence or an indelicacy. That is the reason why, to avoid the danger of being perceived vulgar or illmannered, language users prefer to employ a range of so-called concealing mechanisms ...
Bożena Duda
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Notes on the procedure line search
, 2002 Modifications of the procedure line search in programms solving systems of nonlinear algebraic equations are analysed and ...
Höschl, Cyril
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Joint trade-off optimization algorithm based on cooperative spectrum sensing throughput
Tongxin xuebao, 2011 The achievable data throughput of the cognitive network was modeled to optimize the overhead and performance of the cooperative system thoroughly.Considering the soft data combination decision,the joint trade-off optimization of the local sampling number
Guo-qing JI, Gang WANG, Hong-bo ZHU
doaj
An Efficient Penalty Method without a Line Search for Nonlinear Optimization
AxiomsIn this work, we integrate some new approximate functions using the logarithmic penalty method to solve nonlinear optimization problems. Firstly, we determine the direction by Newton’s method.
Assma Leulmi
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Adaptive Backtracking Line Search
Backtracking line search is foundational in numerical optimization. The basic idea is to adjust the step-size of an algorithm by a constant factor until some chosen criterion (e.g. Armijo, Descent Lemma) is satisfied. We propose a novel way to adjust step-sizes, replacing the constant factor used in regular backtracking with one that takes into account
Joao V. Cavalcanti +2 more
openaire +3 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Automated 3D Tumor Segmentation From Breast DCE-MRI Using Energy-Tuned Minimax Optimization
IEEE AccessBreast cancer (BC) is a multifaceted genetic malignancy that accounts for the majority of cancer fatalities in women. Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is predominant in evaluating perfusion, extravascular-extracellular ...
Priyadharshini Babu +2 more
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source