Results 81 to 90 of about 7,898,408 (287)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
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A novel three-term conjugate gradient approach for deep neural network training [PDF]
Iranian Journal of Numerical Analysis and OptimizationThis paper presents a new three-term conjugate gradient (CG) method for large-scale unconstrained optimization, with application to training deep neural networks.
Faeze Sadat Hosseini-Mighan, Ali Ashrafi
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
An S-Hybridization Technique Using Two-Directional Optimization
AxiomsIn this paper, we study a recently established s-hybrid approach for generating gradient descent methods for solving optimization tasks. We present an s-hybrid variant of the accelerated double-direction method.
Vladimir Rakočević +1 more
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Probabilistic Line Searches for Stochastic Optimization
CoRR, 2015 12 pages, including ...
Mahsereci, M., Hennig, P.
openaire +9 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Job search strategies and social networks : evidence from the Khayelitsha [PDF]
, 2004 Includes bibliographical references (leaves 58-61).The thesis investigates factors which determine the choice of the search method used by the unemployed in looking for jobs.
Schöer, Volker
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AxiomsAn upgrade to the quasi-Newton (QN) family of methods for solving unconstrained optimization problems is proposed. This research focuses on a detailed investigation of the Barzilai and Borwein (BB) gradient methods.
Predrag S. Stanimirović +3 more
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source