Results 61 to 70 of about 7,898,408 (287)
[Central America] : father Neptune presenteth ye Grace Line fleet to ye olde Spanish Main
, 2016 1 Mapa, color. - Mapa pictòric. - `... The informative interest of ths carte is historical and topograpical yet it is rendered in the manner humorous...`.
Grace Line [Companyia naviera]
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
MathematicsThis paper proposes a new proximal iteratively reweighted nuclear norm method for a class of nonconvex and nonsmooth optimization problems. The primary contribution of this work is the incorporation of line search technique based on dimensionality ...
Zhili Ge, Siyu Zhang, Xin Zhang, Yan Cui
doaj +1 more source
A new self –scaling VM-algorithm with an adaptive line search [PDF]
مجلة التربية والعلم, 2010 In this study, a new self-scaling VM algorithm for solving large-scale nonlinear unconstrained optimization problems is proposed. The new algorithm is a kind of line search procedure .The local convergence theory for the BFGS matrix implementation of ...
Abbas. Al-Baiati +2 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Relay UAV motion control method for airborne multi-agent systems
工程科学学报Compared to single-agent systems, multi-agent systems exhibit advantages such as high efficiency and strong survivability in task execution. However, an increase in distance increases the difficulty for agents to communicate with each other and also ...
Cancan TAO, Ronghao WANG
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
AtmosphereThis paper introduces an efficient approach for implementing the Four-Dimensional Variational Ensemble Kalman Filter (4D-EnKF) for non-linear data assimilation, leveraging a modified Cholesky decomposition (4D-EnKF-MC).
Elías D. Nino-Ruiz +1 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source