Results 71 to 80 of about 4,101,702 (289)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Searching for Emission-Line Galaxies [PDF]
International Astronomical Union Colloquium, 1984 Survey methods for finding emission-line galaxies are reviewed. Observational selection effects are investigated by comparing different surveys and the limitations of the different techniques are discussed. The advantages of Ha surveys for finding low luminosity galaxies and those with low excitation emission spectra are emphasized.
openaire +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Spectral variability of planetary nebulae and related objects
, 2006 The results of long-term spectral observations were used to search for changes in planetary nebulae and emission-line stars.
Acker A. +8 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
MathematicsThis paper proposes a new proximal iteratively reweighted nuclear norm method for a class of nonconvex and nonsmooth optimization problems. The primary contribution of this work is the incorporation of line search technique based on dimensionality ...
Zhili Ge, Siyu Zhang, Xin Zhang, Yan Cui
doaj +1 more source
A new self –scaling VM-algorithm with an adaptive line search [PDF]
مجلة التربية والعلم, 2010 In this study, a new self-scaling VM algorithm for solving large-scale nonlinear unconstrained optimization problems is proposed. The new algorithm is a kind of line search procedure .The local convergence theory for the BFGS matrix implementation of ...
Abbas. Al-Baiati +2 more
doaj +1 more source
, 2018 In this paper, we propose a successive convex approximation framework for sparse optimization where the nonsmooth regularization function in the objective function is nonconvex and it can be written as the difference of two convex functions. The proposed
Chatzinotas, Symeon +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source