Results 111 to 120 of about 4,101,702 (289)

An Efficient Penalty Method without a Line Search for Nonlinear Optimization

Axioms
In this work, we integrate some new approximate functions using the logarithmic penalty method to solve nonlinear optimization problems. Firstly, we determine the direction by Newton’s method.
Assma Leulmi
doaj   +1 more source

Adaptive Backtracking Line Search

Backtracking line search is foundational in numerical optimization. The basic idea is to adjust the step-size of an algorithm by a constant factor until some chosen criterion (e.g. Armijo, Descent Lemma) is satisfied. We propose a novel way to adjust step-sizes, replacing the constant factor used in regular backtracking with one that takes into account
Joao V. Cavalcanti, Laurent Lessard, Ashia C. Wilson   +2 more
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Sensitive Search for [N II]205 μm Emission in a z = 6.4 Quasar Host Galaxy [PDF]

, 2009
We present a sensitive search for the 3P1 → 3P0 ground-state fine structure line at 205 μm of ionized nitrogen ([N II]205μm) in one of the highest-redshift quasars (J1148+5251 at z = 6.42) using the IRAM 30 m telescope. The line is not detected at a (3σ)
Bertoldi, Frank, Carilli, Christopher L., Cox, Pierre, Menten, Karl M., Riechers, Dominik A., Walter, Fabian, Weiss, Axel   +6 more
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Automated 3D Tumor Segmentation From Breast DCE-MRI Using Energy-Tuned Minimax Optimization

IEEE Access
Breast cancer (BC) is a multifaceted genetic malignancy that accounts for the majority of cancer fatalities in women. Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is predominant in evaluating perfusion, extravascular-extracellular ...
Priyadharshini Babu, Mythili Asaithambi, Sudhakar Mogappair Suriyakumar   +2 more
doaj   +1 more source

Fast Convergence Strategy for Multi-Image Superresolution via Adaptive Line Search

IEEE Access, 2018
Multi-image superresolution (SR) techniques produce a high-resolution image from several low-resolution observations. Previous reconstruction-based SR approaches focus more on the optimization models but have not adequately emphasized the mathematic ...
Yingqian Wang, Jungang Yang, Chao Xiao, Wei An   +3 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Nonlinear Conjugate Gradient Methods with Wolfe Type Line Search

Abstract and Applied Analysis, 2013
Nonlinear conjugate gradient method is one of the useful methods for unconstrained optimization problems. In this paper, we consider three kinds of nonlinear conjugate gradient methods with Wolfe type line search for unstrained optimization problems ...
Yuan-Yuan Chen, Shou-Qiang Du
doaj   +1 more source