Results 41 to 50 of about 820,651 (313)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell +14 more
wiley +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
MathematicsUnconstrained optimization problems have a long history in computational mathematics and have been identified as being among the crucial problems in the fields of applied sciences, engineering, and management sciences. In this paper, a new variant of the
Aliyu Muhammed Awwal +3 more
doaj +1 more source
An Efficient Line Search Algorithm for Large Scale Optimization [PDF]
Al-Rafidain Journal of Computer Sciences and Mathematics, 2010 In this work we present a new algorithm of gradient descent type, in which the stepsize is computed by means of simple approximation of the Hessian Matrix to solve nonlinear unconstrained optimization function.
Abbas Al-Bayati, Ivan Latif
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
A Combined Cubic and Novel Line Search CG-Algorithm [PDF]
Al-Rafidain Journal of Computer Sciences and Mathematics, 2012 In this paper a new line search technique is investigated. It uses (cubic and novel) line searches in the standard CG-algorithm for unconstrained optimization.
Abbas Al-Bayati, Hamsa Chilmerane
doaj +1 more source
Relationship between Batch Size and Number of Steps Needed for Nonconvex Optimization of Stochastic Gradient Descent using Armijo Line Search [PDF]
, 2023 Yuki Tsukada, Hideaki Iiduka
openalex +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source