Results 111 to 120 of about 137,568 (296)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Combining ability and heterosis on millable stalk and sugar concentration for bioethanol production across environments in sweet sorghum (Sorghum bicolor (L.) Moench.) [PDF]

Electronic Journal of Plant Breeding, 2015
Combining ability studies involving five females, six males and 30 hybrids respectively at three semi-arid locations by following a line x tester mating design.
D.M. Bahadure, Shailesh Marker, A.V. Umakanth, Prabhakar,P.W.Ramteke, J.v. Patil and B.S. Rana
doaj  

An improved evaluation of surface finish with a three dimensional tester [PDF]

The design and programming of an automated three dimensional surface finish tester is described. The device produces a three dimensional image of the microscopic texture of the examined surface. The surface finish tester presents the following advantages
GRANDADAM, PREBET, RIOUT
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Combining ability study for yield and quality traits in cucumber (Cucumis sativus L.)

Electronic Journal of Plant Breeding, 2020
Seven cucumber (Cucumissativus L.) genotypes (3 lines and 4 testers) were crossed in a line × tester mating design. The resultant 12 hybrids and their parents were evaluated using Randomised Block Design with two replications during Kharif 2018 ...
K. Rajaguru, T. Arumugam, D. Sassi kumar and S. Jeeva
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Combining ability and gene action studies for seed yield and its components in Sunflower (Helianthus annuus L.) [PDF]

Electronic Journal of Plant Breeding, 2012
Five CMS lines and six restorers were crossed in a line x tester fashion to elucidate the information on the combining abilityfor seed yield, yield components and oil content and also to know the nature of gene action involved in inheritance of important
Raghunath Patil, I. Shaker Goud, Vikas Kulkarni and Chetankumar Banakar
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Assessment of combining ability and genetic parameters for yield and fiber traits in upland cotton (Gossypium hirsutum L.) using Line × Tester analysis

Electronic Journal of Plant Breeding
Seed cotton yield and fiber quality are two critical parameters that fundamentally define the economic and industrial value of cotton. The present work focused on improving cotton genotypes both for yield and quality parameters through intraspecific ...
B. Aishwarya1*, B. R. Patil1, R. S. Patil2, M. G. Hegde3 and M. S. L. Rao4
doaj   +1 more source

Software for physics of tau lepton decay in LHC experiments

, 2010
Software development in high energy physics experiments offers unique experience with rapidly changing environment and variety of different standards and frameworks that software must be adapted to.
Przedzinski, Tomasz
core