Results 251 to 260 of about 1,099,358 (342)

Spatio-temporal patterns of tuberculosis revealed by routine <i>Mycobacterium tuberculosis</i> sequencing in Australia: an extended patient cohort analysis (2017-2023). [PDF]

Lancet Reg Health West Pac
Zhang X, Suster CJE, Sim EM, Lam C, Martinez E, Crighton T, Donnan EJ, Marais BJ, Sintchenko V.   +8 more
europepmc   +1 more source

Phylogenetic analysis of microsatellite markers further supports the two hybridization events hypothesis as the origin of the Trypanosoma cruzi lineages

, 2009
Juan Venegas, William Coñoepán, Sergio Pîchuantes, Sandra Miranda, María Isabel Jercic, Marta Gajardo, Gittith Sánchez   +6 more
openalex   +2 more sources

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

BRCA1: An Unrecognized Modulator of Lineage Plasticity in Basal-like Breast Cancer. [PDF]

J Mammary Gland Biol Neoplasia
Sanawar R, Sengodan SK.
europepmc   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

ScisTree2 enables large-scale inference of cell lineage trees and genotype calling using efficient local search. [PDF]

Genome Res
Zhang H, Zhang Y, Gao T, Wu Y.
europepmc   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

TFEB-mediated autophagy stimulation as an anabolic strategy for bone: insights from TFEB activation in the osteoblast lineage. [PDF]

Autophagy Rep
Onal M.
europepmc   +1 more source

A pragmatic pipeline for drug resistance and lineage identification in Mycobacterium tuberculosis using whole genome sequencing

Linzy Elton, Alp Aydin, Neil G. Stoker, Sylvia Rofael, Letícia Muraro Wildner, Jabar Babatunde Pacome Agbo Achimi Abdul, John Tembo, Muzamil Mahdi Abdel Hamid, Mfoutou Mapanguy Claujens Chastel, Julio Ortiz Canseco, Ronan Doyle, Giovanni Satta, Justin O’Grady, Adam A. Witney, Francine Ntoumi, Alimuddin Zumla, Timothy D. McHugh   +16 more
openalex   +1 more source