Results 41 to 50 of about 1,099,358 (342)

Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus [PDF]

, 2017
Background: A group A Streptococcus (GAS) lineage of genotype emm3, sequence type 15 (ST15) was associated with a six month upsurge in invasive GAS disease in the UK.
Afshar, B, Al-Shahib, A, Efstratiou, A, Holden, M T G, Lamagni, T L, Smith, K C, Sriskandan, S, Turner, C E, Underwood, A   +8 more
core   +3 more sources

Lopo Fernandes Pacheco: um valido de D. Afonso IV

Medievalista, 2014
The Lopo Fernandes Pacheco gothic tomb, located inside Lisbon’s Cathedral in S. Cosme e S. Damião Chapel, has been attracted the attention of many authors. Nevertheless few things are known about this man, who fills a prominence position in the D. Afonso
Vanda Lourenço
doaj   +1 more source

Molecular recording of mammalian embryogenesis. [PDF]

, 2019
Ontogeny describes the emergence of complex multicellular organisms from single totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate relationship between self-renewal and differentiation, variation in progenitor
Adamson, Britt, Chan, Michelle M, Grosswendt, Stefanie, Jones, Matthew G, Jost, Marco, Khodaverdian, Alex, Kretzmer, Helene, Meissner, Alexander, Norman, Thomas M, Quinn, Jeffrey J, Smith, Zachary D, Weissman, Jonathan S, Yang, Dian, Yosef, Nir   +13 more
core   +2 more sources

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source

Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies

Signal Transduction and Targeted Therapy
The upper respiratory tract is the initial site of SARS-CoV-2 infection. Nasal spike-specific secretory immunoglobulin A (sIgA) correlates with protection against Omicron breakthrough infection.
Si Chen, Zhengyuan Zhang, Qian Wang, Qi Yang, Li Yin, Lishan Ning, Zhilong Chen, Jielin Tang, Weiqi Deng, Ping He, Hengchun Li, Linjing Shi, Yijun Deng, Zijian Liu, Hemeng Bu, Yaohui Zhu, Wenming Liu, Linbing Qu, Liqiang Feng, Xiaoli Xiong, Baoqing Sun, Nanshan Zhong, Feng Li, Pingchao Li, Xinwen Chen, Ling Chen   +25 more
doaj   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Decoupling Lineage-Associated Genes in Acute Myeloid Leukemia Reveals Inflammatory and Metabolic Signatures Associated With Outcomes

Frontiers in Oncology, 2021
Acute myeloid leukemia (AML) is a heterogeneous disease with variable responses to therapy. Cytogenetic and genomic features are used to classify AML patients into prognostic and treatment groups.
Hussein A. Abbas, Vakul Mohanty, Ruiping Wang, Yuefan Huang, Yuefan Huang, Shaoheng Liang, Shaoheng Liang, Feng Wang, Jianhua Zhang, Yihua Qiu, Chenyue W. Hu, Amina A. Qutub, Monique Dail, Christopher R. Bolen, Naval Daver, Marina Konopleva, Andrew Futreal, Ken Chen, Linghua Wang, Steven M. Kornblau   +19 more
doaj   +1 more source

Two Distinct, Geographically Overlapping Lineages of the Corallimorpharian Ricordea Florida (Cnidaria: Hexacorallia: Ricordeidae) [PDF]

, 2011
We examined the genetic variation of the corallimorpharian Ricordea florida; it is distributed throughout the Caribbean region and is heavily harvested for the marine aquarium trade. Eighty-four distinct individuals of R. florida were sequenced from four
Lado-Insua, T., Rhyne, Andrew L., Rodríguez-Matos, L., Schizas, N. V., Torres-Pratts, H.   +4 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

A single-cell hematopoietic microenvironmental atlas reveals progressive maturation of bone marrow vascular niche

Cell Regeneration
The interaction between hematopoietic stem and progenitor cell (HSPC) and its vascular niche is essential for supporting the homeostasis and reconstitution of hematopoietic system in adult bone marrow (BM), but a comprehensive atlas covering this HSPC ...
Lan-Yue Ma, Zhao-Hua Deng, Ke Bai, Yan-Mei Yu, Yin Huang, Rong-Rong Gao, Yu-Yan Li, Xiao-Ling Li, Jia-Xin Yang, Ya-Hai Shu, Jinjin Ma, Yang Liu, Qi Chen   +12 more
doaj   +1 more source