Results 61 to 70 of about 1,099,358 (342)

Premature aging effects on COVID-19 pathogenesis: new insights from mouse models

Scientific Reports
Aging is identified as a significant risk factor for severe coronavirus disease-2019 (COVID-19), often resulting in profound lung damage and mortality.
Wu Haoyu, Liu Meiqin, Sun Jiaoyang, Hong Guangliang, Lin Haofeng, Chen Pan, Quan Xiongzhi, Wu Kaixin, Hu Mingli, Yang Xuejie, Ingo Lämmermann, Johannes Grillari, Shi Zhengli, Chen Jiekai, Wu Guangming   +14 more
doaj   +1 more source

Comparative Study on Tuberculosis Drug Resistance and Molecular Detection Methods Among Different Mycobacterium Tuberculosis Lineages

Infection and Drug Resistance, 2023
Chuan-Jiang He,1,2 Jiang-Li Wan,2 Sheng-Fang Luo,2 Rui-Jie Guo,2 Pawuziye Paerhati,2 Xiang Cheng,2 Chao-Hui Duan,1,* Ai-Min Xu2,* 1Department of Laboratory Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’
He CJ, Wan JL, Luo SF, Guo RJ, Paerhati P, Cheng X, Duan CH, Xu AM   +7 more
doaj  

Origins of the avian neural crest: the role of neural plate-epidermal interactions [PDF]

, 1995
We have investigated the lineage and tissue interactions that result in avian neural crest cell formation from the ectoderm. Presumptive neural plate was grafted adjacent to non-neural ectoderm in whole embryo culture to examine the role of tissue ...
Bronner-Fraser, Marianne, Selleck, Mark A. J.   +1 more
core  

Using schema transformation pathways for data lineage tracing [PDF]

, 2005
With the increasing amount and diversity of information available on the Internet, there has been a huge growth in information systems that need to integrate data from distributed, heterogeneous data sources. Tracing the lineage of the integrated data is
A. Woodruff, C. Faloutsos, H. Fan, H. Fan, H. Fan, J. Albert, L. Zamboulis, L. Zamboulis, M. Boyd, P. Buneman, P. Buneman, P. McBrien, P. McBrien, P.A. Bernstein, Y. Cui, Y. Cui, Y. Cui   +16 more
core   +4 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Enhancing human ACE2 expression in mouse models to improve COVID‐19 research

FEBS Open Bio
Mice are one of the most common biological models for laboratory use. However, wild‐type mice are not susceptible to COVID‐19 infection due to the low affinity of mouse ACE2, the entry protein for SARS‐CoV‐2.
Sun Jiaoyang, Cheng Shaofei, Hong Guangliang, Quan Xiongzhi, Lin Haofeng, Mao Rui, Johannes Grillari, Shi Zheng‐Li, Chen Jiekai, Liu Meiqin, Wu Haoyu, Wu Guangming   +11 more
doaj   +1 more source

An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape

Frontiers in Immunology
BackgroundAlthough immunoglobulin (Ig) alleles play a pivotal role in the antibody response to pathogens, research to understand their role in the humoral immune response is still limited.MethodsWe retrieved the germline sequences for the IGHV from the ...
Weiqi Deng, Weiqi Deng, Xuefeng Niu, Ping He, Ping He, Qihong Yan, Qihong Yan, Huan Liang, Yongping Wang, Yongping Wang, Lishan Ning, Lishan Ning, Zihan Lin, Zihan Lin, Yudi Zhang, Xinwei Zhao, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen, Ling Chen   +20 more
doaj   +1 more source

Discovery of a Lineage of Soil-Dwelling Medetera Species with Multi-Coloured Eyes in Southern Europe (Diptera: Dolichopodidae) [PDF]

, 2022
Marc A. A. Pollet, Rui Andrade, Ana Rita Gonçalves, Piluca Álvarez Fidalgo, José Luís Camaño Portela, F. Belin, Jonas Mortelmans, Andreas Stark   +7 more
openalex   +1 more source

Association between genotypic diversity and biofilm production in group B Streptococcus [PDF]

, 2016
Background: Group B Streptococcus (GBS) is a leading cause of sepsis and meningitis and an important factor in premature and stillbirths. Biofilm production has been suggested to be important for GBS pathogenesis alongside many other elements ...
Davies, H. Dele, Gaddy, Jennifer A., Laut, Clare, Manning, Shannon D., Parker, Robert E., Zadoks, Ruth   +5 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source