Results 61 to 70 of about 1,050,104 (292)

Revision of Coprosma (Rubiaceae, tribe Anthospermeae) in the Marquesas Islands [PDF]

, 2011
During the preparation of the Vascular Flora of the Marquesas Islands three new species of Coprosma (Rubiaceae, tribe Anthospermeae) have come to light and are described herein: C. fatuhivaensis W. L. Wagner & Lorence, C. meyeri W. L.
Wagner, Warren, Lorence, David
core   +2 more sources

Premature aging effects on COVID-19 pathogenesis: new insights from mouse models

Scientific Reports
Aging is identified as a significant risk factor for severe coronavirus disease-2019 (COVID-19), often resulting in profound lung damage and mortality.
Wu Haoyu, Liu Meiqin, Sun Jiaoyang, Hong Guangliang, Lin Haofeng, Chen Pan, Quan Xiongzhi, Wu Kaixin, Hu Mingli, Yang Xuejie, Ingo Lämmermann, Johannes Grillari, Shi Zhengli, Chen Jiekai, Wu Guangming   +14 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Vimentin downregulation is an inherent feature of murine erythropoiesis and occurs independently of lineage [PDF]

, 1990
In mammalian erythropoiesis, the mature cells of the primitive lineage remain nucleated while those of the definitive lineage are anuclear. One of the molecular and structural changes that precedes enucleation in cells of the definitive lineage is the ...
Lazarides, Elias, Sangiorgi, Frank, Woods, Catherine M.   +2 more
core  

Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing [PDF]

, 2017
Tendon injuries heal via scar tissue rather than regeneration. This healing response forms adhesions between the flexor tendons in the hand and surrounding tissues, resulting in impaired range of motion and hand function.
Ackerman, Jessica E, Best, Katherine T, Loiselle, Alayna E, O’Keefe, Regis J   +3 more
core   +2 more sources

A Clonal NG2-Glia Cell Response in a Mouse Model of Multiple Sclerosis

Cells, 2020
NG2-glia, also known as oligodendrocyte precursor cells (OPCs), have the potential to generate new mature oligodendrocytes and thus, to contribute to tissue repair in demyelinating diseases like multiple sclerosis (MS).
Sonsoles Barriola, Fernando Pérez-Cerdá, Carlos Matute, Ana Bribián, Laura López-Mascaraque   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Enhancing human ACE2 expression in mouse models to improve COVID‐19 research

FEBS Open Bio
Mice are one of the most common biological models for laboratory use. However, wild‐type mice are not susceptible to COVID‐19 infection due to the low affinity of mouse ACE2, the entry protein for SARS‐CoV‐2.
Sun Jiaoyang, Cheng Shaofei, Hong Guangliang, Quan Xiongzhi, Lin Haofeng, Mao Rui, Johannes Grillari, Shi Zheng‐Li, Chen Jiekai, Liu Meiqin, Wu Haoyu, Wu Guangming   +11 more
doaj   +1 more source

Comparative Study on Tuberculosis Drug Resistance and Molecular Detection Methods Among Different Mycobacterium Tuberculosis Lineages

Infection and Drug Resistance, 2023
Chuan-Jiang He,1,2 Jiang-Li Wan,2 Sheng-Fang Luo,2 Rui-Jie Guo,2 Pawuziye Paerhati,2 Xiang Cheng,2 Chao-Hui Duan,1,* Ai-Min Xu2,* 1Department of Laboratory Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’
He CJ, Wan JL, Luo SF, Guo RJ, Paerhati P, Cheng X, Duan CH, Xu AM   +7 more
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source