Results 91 to 100 of about 533,076 (344)

A Unifying Scenario on the Origin and Evolution of Cellular and Viral Domains [PDF]

, 2009
The cellular theory on the nature of life has been one of the first major advancements in biology. Viruses, however, are the most abundant life forms, and their exclusion from mainstream biology and the Tree of Life (TOL) is a major paradox in biology ...
Claudiu I. Bandea
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Specific Preferences in Lineage Choice and Phenotypic Plasticity of Glioma Stem Cells Under BMP4 and Noggin Influence [PDF]

, 2015
Although BMP4-induced differentiation of glioma stem cells (GSCs) is well recognized, details of the cellular responses triggered by this morphogen are still poorly defined.
Arakaki, Naomi, Fernandez Espinosa, Damian Dario, Garcia, Carolina Paola, Martinetto, Horacio Enrique, Miriuka, Santiago Gabriel, Roisman, Alejandro, Romorini, Leonardo, Scassa, Maria Elida, Sevlever, Gustavo Emilio, Slavutsky, Irma Rosa, Videla Richardson, Guillermo Agustín   +10 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Evolution of microgastropods (Ellobioidea, Carychiidae): integrating taxonomic, phylogenetic and evolutionary hypotheses [PDF]

, 2013
BACKGROUND: Current biodiversity patterns are considered largely the result of past climatic and tectonic changes. In an integrative approach, we combine taxonomic and phylogenetic hypotheses to analyze temporal and geographic diversification of epigean (
Adrienne Jochum, Alexander M Weigand, Annette Klussmann-Kolb, Eugenia Zarza, Jan nges ar Schnitzler, Rajko Slapnik, Weigand, Alexander M   +6 more
core   +1 more source

Genetic Isolation among Four Lineages of Silene nutans

Plant And Cell Physiology
Abstract Speciation is the process leading to the emergence of new species. While being usually progressive, it can sometimes be fast with rapid emergence of reproductive barriers leading to high level of reproductive isolation.
Postel, Zoé, Martin, Hélène, Roux, Camille, Godé, Cécile, Genete, Mathieu, Schmitt, Éric, Monnet, François, Vekemans, Xavier, Touzet, Pascal   +8 more
openaire   +2 more sources

Evidence of cryptic genetic lineages within Aedes notoscriptus (Skuse)

Infection, Genetics and Evolution, 2013
Aedes notoscriptus (Skuse), a mosquito from the southwest Pacific region including Australia, has been implicated as a vector of arboviruses, but its status as a species is unclear. To investigate the taxonomic situation, we assessed genetic variation and phylogenetic relationships among Ae.
Nancy M, Endersby, Vanessa L, White, Janice, Chan, Tim, Hurst, Gordana, Rašić, Adam, Miller, Ary A, Hoffmann   +6 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Genetic diversity of the Aporrectodea caliginosa complex in Russia

Вавиловский журнал генетики и селекции, 2017
Earthworms of the Aporrectodea caliginosa species complex are abundant in many anthropogenic and natural habitats and often predominate in earthworm communities. In Russia, there are two subspecies of the complex, A. c. caliginosa and A. c.
S. V. Shekhovtsov, E. V. Golovanova, N. E. Bazarova, Yu. N. Belova, D. I. Berman, E. A. Derzhinsky, M. P. Shashkov, S. E. Peltek   +7 more
doaj   +1 more source

Mitochondrial DNA analysis of eneolithic trypillians from Ukraine reveals neolithic farming genetic roots [PDF]

, 2017
The agricultural revolution in Eastern Europe began in the Eneolithic with the Cucuteni-Trypillia culture complex. In Ukraine, the Trypillian culture (TC) existed for over two millennia (ca. 5,400–2,700 BCE) and left a wealth of artifacts.
Lillie, Malcolm, Mallick, Swapan, Nikitin, Alexey, Nikitin, Alexey G., Potekhina, Inna, Potiekhina, I D, Reich, David, Rohland, Nadin   +7 more
core   +1 more source