Results 101 to 110 of about 3,416,725 (336)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Genetic Evolution and Molecular Selection of the HE Gene of Influenza C Virus [PDF]

, 2019
Influenza C virus (ICV) was first identified in humans and swine, but recently also in cattle, indicating a wider host range and potential threat to both the livestock industry and public health than was originally anticipated.
He, Wanting, Li, Gairu, Su, Shuo, Veit, Michael, Wang, Congcong, Wen, Baiqing, Xu, Qiuhua, Zhang, Letian, Zhang, Wenyan, Zhang, Xu, Zhou, Jiyong   +10 more
core   +1 more source

THE GENOMIC LANDSCAPE OF PEDIATRIC AND YOUNG ADULT T-LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA

Nature Genetics, 2017
Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute lymphoblastic leukemia (T-ALL), but detailed genome-wide sequencing of ...
Yu Liu, J. Easton, Ying Shao, J. Maciaszek, Zhaoming Wang, M. Wilkinson, K. McCastlain, Michael N. Edmonson, S. Pounds, Lei Shi, Xin Zhou, Xiaotu Ma, Edgar Sioson, Yongjin Li, Michael C. Rusch, P. Gupta, Deqing Pei, Cheng Cheng, Malcolm A. Smith, J. G. Auvil, D. Gerhard, M. Relling, N. Winick, A. Carroll, N. Heerema, E. Raetz, M. Devidas, C. Willman, R. Harvey, W. Carroll, K. Dunsmore, S. Winter, B. Wood, B. Sorrentino, J. Downing, M. Loh, S. Hunger, Jinghui Zhang, C. Mullighan   +38 more
semanticscholar   +1 more source

Genetic investigation within Lactococcus garvieae revealed two genomic lineages [PDF]

FEMS Microbiology Letters, 2012
The diversity of a collection of 49 Lactococcus garvieae strains, including isolates of dairy, fish, meat, vegetable and cereal origin, was explored using a molecular polyphasic approach comprising PCR-ribotyping, REP and RAPD-PCR analyses and a multilocus restriction typing (MLRT) carried out on six partial genes (atpA, tuf, dltA, als, gapC, and galP).
C. Ferrario, G. Ricci, F. Borgo, A. Rollando, M.G. Fortina   +4 more
openaire   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Mitochondrial DNA Variation of Feral Honey Bees (Apis mellifera L.) from Utah (USA)

Journal of Apicultural Science, 2018
A study was conducted on the mitochondrial DNA genetic diversity of feral colonies and swarms of Apis mellifera from ten counties in Utah by sequencing the intergenic region of the cytochrome oxidase (COI-COII) gene region.
Cleary Dylan, Szalanski Allen L., Trammel Clinton, Williams Mary-Kate, Tripodi Amber, Downey Danielle   +5 more
doaj   +1 more source

Pseudobarbus outeniqua sp. nov., a new redfin species (Teleostei, Cyprinidae) from the Cape Fold Ecoregion of South Africa [PDF]

ZooKeys
Previous DNA-based studies identified four genetic lineages within Pseudobarbus afer: (i) the Mandela lineage confined to the Sundays, Swartkops, and Baakens river systems, (ii) the Krom lineage endemic to the Krom River system, (iii) the St Francis ...
Fatah Zarei, Pedro H. N. Bragança, Paul H. Skelton, Albert Chakona   +3 more
doaj   +3 more sources

Computational inference beyond Kingman's coalescent [PDF]

, 2015
Full likelihood inference under Kingman's coalescent is a computationally challenging problem to which importance sampling (IS) and the product of approximate conditionals (PAC) method have been applied successfully.
Jenkins, Paul, Koskela, Jere, Spanò, Dario   +2 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Kinship, lineage identity, and an evolutionary perspective on the structure of cooperative big game hunting groups in Indonesia. [PDF]

, 2002
Work was conducted among traditional, subsistence whale hunters in Lamalera, Indonesia in order to test if kinship or lineage membership is more important for explaining the organization of cooperative hunting parties ranging in size from 8-14 men.
Alvard, Dr. Michael
core