Results 271 to 280 of about 533,076 (344)

Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1‐Mediated Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Neural stem cell transplantation shows promise for spinal cord repair, but poor graft survival limits therapeutic efficacy. This study demonstrates that increasing hydrogel stiffness from 10% to 16% concentration significantly enhances transplanted neural stem cell survival through Piezo1‐mediated mechanotransduction, revealing mechanical properties as
Hee Hwan Park   +19 more
wiley   +1 more source

Analysis of genetic variations of a recombinant strain derived from the three lineages of porcine reproductive and respiratory syndrome virus-2

open access: diamond
Limei Zheng   +14 more
openalex   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang   +18 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

open access: yesAdvanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao   +16 more
wiley   +1 more source

Global Diversification Rates of Ferns Across Spatial and Climatic Gradients

open access: yesAdvanced Science, EarlyView.
Diversification rates of fern genera across the phylogeny. Abstract Geographic patterns of diversity in any group of plants are the result of the interplay of environmental conditions and the evolutionary dynamics of the respective plant group. Here, the geographic distribution of current mean diversification rates (MDR) is explored at the genus level ...
Hong Qian, Michael Kessler, Shenhua Qian
wiley   +1 more source

Haemoproteus syrnii and other haemosporidians infecting owls from North America. [PDF]

open access: yesMalar J
Pacheco MA   +9 more
europepmc   +1 more source

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