Results 71 to 80 of about 503,355 (348)

Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. [PDF]

, 2018
Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been proposed, but complete understanding of the spectrum of ...
Blake, Kerrigan, Davis, Ryan Tevia, Driver, Ian, Goga, Andrei, Jabart, Eric, James, Nathan, Kessenbrock, Kai, Khan, Seema A, Kumar, Raj, Lawson, Devon A, Ma, Dennis, Nguyen, Quy H, Pervolarakis, Nicholas, Phung, Anh T, Rock, Jason, Werb, Zena, Willey, Elizabeth   +16 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Towards a digital model of zebrafish embryogenesis. Integration of Cell Tracking and Gene Expression Quantification [PDF]

, 2010
We elaborate on a general framework composed of a set of computational tools to accurately quantificate cellular position and gene expression levels throughout early zebrafish embryogenesis captured over a time-lapse series of in vivo 3D images.
Bourgine, Paul, Castro González, Carlos, Desnoulez, Sophie, Douloquin, Louise, Ledesma Carbayo, María Jesús, Luengo Oroz, Miguel Ángel, Melani, Camilo, Peyrieras, Nadine, Santos Lleo, Andres de, Savy, Thierry   +9 more
core   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Lineages of the Cardiac Conduction System

Journal of Cardiovascular Development and Disease, 2017
The cardiac conduction system (CCS) initiates and coordinately propagates the electrical impulse to orchestrate the heartbeat. It consists of a set of interconnected components with shared properties.
Rajiv Mohan, Bas J. Boukens, Vincent M. Christoffels   +2 more
doaj   +1 more source

A review of Bennelongia De Deckker & McKenzie, 1981 (Crustacea, Ostracoda) species from eastern Australia with the description of three new species [PDF]

, 2012
Australia is predicted to have a high number of currently undescribed ostracod taxa. The genus Bennelongia De Deckker & McKenzie, 1981 (Crustacea, Ostracoda) occurs in Australia and New Zealand, and has recently shown potential for high speciosity, after
Halse, Stuart, Koenders, Annette, Martens, Koen, Schön, Isa, Shearn, Rylan   +4 more
core   +4 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Pseudobarbus outeniqua sp. nov., a new redfin species (Teleostei, Cyprinidae) from the Cape Fold Ecoregion of South Africa [PDF]

ZooKeys
Previous DNA-based studies identified four genetic lineages within Pseudobarbus afer: (i) the Mandela lineage confined to the Sundays, Swartkops, and Baakens river systems, (ii) the Krom lineage endemic to the Krom River system, (iii) the St Francis ...
Fatah Zarei, Pedro H. N. Bragança, Paul H. Skelton, Albert Chakona   +3 more
doaj   +3 more sources

Helmet Shape and Phylogeography of the Treehopper Membracis mexicana

Insects, 2023
Membracis mexicana (Hemiptera: Membracidae) is distributed in four biogeographic provinces of Mexico. Field observations indicate that there are different forms of this species, but the distribution of the phenotype and the genetic variation of this ...
Marisol De-la-Mora, Daniel Pinero
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source