Results 161 to 170 of about 107,950 (242)

Molecular evolution and spatial transmission of severe fever with thrombocytopenia syndrome virus. [PDF]

Nat Commun
Leng Y, Mu HZ, Cui N, Fang LT, Wang R, Ni XY, Li S, Ge HH, Dai ZN, Wang R, Wang X, Yang X, Wu BZ, Zhang XA, Wang ZF, Ye L, Li H, Cao GW, Liu W.   +18 more
europepmc   +1 more source

Deciphering oligodendrocyte lineage heterogeneity in development and disease

Oligodendrocytes are the myelinating glia of the central nervous system (CNS). By forming lipid-rich myelin membranes that spirally enwrap axonal segments, oligodendrocytes ensure rapid saltatory impulse propagation, structural integrity, and metabolic ...
Petra Kukanja (18683884)
core  

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Leukemia Cutis at Initial Diagnosis of Acute Myeloid Leukemia Consistent With Therapy-Related Disease After Lung Cancer Chemotherapy: A Case Report. [PDF]

Case Rep Hematol
Bowen A, DiLoreto N, Bayya M, McDonald R, Isaac D.   +4 more
europepmc   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Evaluation of candidate reference materials for the harmonization of Lassa fever serology. [PDF]

Emerg Microbes Infect
Bentley EM, Ithete N, Mitchell J, Richardson SAS, Bernasconi V, Killip M, Garry RF, Branco L, Günther S, Atkinson E, Rigsby P, Hinrichs M, Oestereich L, Thielebein A, Omoifo V, Omiunu R, Esumeh R, Okogbenin S, Kristiansen PA, Page M, Ogbaini-Emovon E, Mattiuzzo G, Collaborative Study Participants.   +22 more
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Genetic genealogy of the Piast dynasty and related European royal families. [PDF]

Nat Commun
Zenczak M, Handschuh L, Marcinkowska-Swojak M, Stolarek I, Golubiński M, Juras A, Trzciński D, Chyleński M, Dębski A, Losik A, Jasiński T, Wrzesińska A, Matla M, Kóčka-Krenz H, Legocki AB, Dobosz J, Figlerowicz M.   +16 more
europepmc   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

The Use of Single-Cell Mitochondrial DNA SNP Combinations for Distinguishing Organ-Specific Cell Types. [PDF]

Cells
Wang S, Tu X, Zhu H, Gao C, Gao J, Wei J, Shi H, Peng J.   +7 more
europepmc   +1 more source