Results 201 to 210 of about 314,656 (291)

Whole-Genome Characterization of Rare Artiodactyl-Like G10P [14] and G8P [14] Rotavirus a Strains Detected in Pediatric Gastroenteritis Cases in Hokkaido Prefecture, Japan. [PDF]

J Med Virol
Takebayashi A, Fukuda Y, Fujii Y, Nihira H, Kihara M, Kudou Y, Adachi S, Shintani N, Tsugawa T.   +8 more
europepmc   +1 more source

Heuristically Adaptive Diffusion‐Model Evolutionary Strategy

Advanced Science, EarlyView.
Building on the mathematical equivalence between diffusion models and evolutionary algorithms, researchers demonstrate unprecedented control over evolutionary optimization through conditional diffusion. By training diffusion models to associate parameters with specific traits, they can guide evolution toward solutions exhibiting desired behaviors ...
Benedikt Hartl, Yanbo Zhang, Hananel Hazan, Michael Levin   +3 more
wiley   +1 more source

Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

Advanced Science, EarlyView.
Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...
Enzhe Lou, Peilong Lai, Guanjie Peng, Bo Lu, Lizhen Jiang, Xinyue Li, Jinghong Chen, Ladi Mo, Qiong Mao, Haichuan Zhang, Jinxin Fang, Yi Meng, Aochu Liu, Yingyin Gao, Andong Huang, Wenhui Lin, Shiwen Hu, Zerong Guan, Xiaolan Ye, Zhenguo Liu, Liling Jiang, Yueyuan Zheng, Xianping Shi   +22 more
wiley   +1 more source

Therapeutic Activities of Multipotent Stromal Cells for Islet Regeneration. [PDF]

Cells
Rasiwala N, Bell GI, Al-Banaa NN, Hess DA.   +3 more
europepmc   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Genomic characterization and evolution analysis of peste des petits ruminants virus in China from 2007 to 2024. [PDF]

Front Microbiol
Bao J, Jiang R, Wang S, Wang Q, Xu J, Zhao Y, Liu Y, Li L, Wang X, Wang Z.   +9 more
europepmc   +1 more source

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

Genomic Surveillance and Antigenic Characterization of Respiratory Syncytial Virus (RSV) in Spain During the 2023-2024 Season of Nirsevimab Administration. [PDF]

J Infect Dis
Iglesias-Caballero M, Mas V, Campoy A, Calvo C, García ML, Alcolea S, Moreno-Parrado L, Reina J, Navascués A, Antón A, Davina-Nunez C, Perez-Castro S, Costa J, Fernández-González A, Lepe JA, Gaona C, Pérez Z, García-Martínez de Artola D, Vázquez-Morón S, Camarero S, Cano O, Pozo F, Casas I.   +22 more
europepmc   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

A centralized interactive tool for genomic data on heat shock protein 90 in Fagaceae species. [PDF]

BMC Genomics
Postigo-Luque R, Guijo-Rubio D, Martín MÁ, Castro P, Die JV.   +4 more
europepmc   +1 more source