Results 161 to 170 of about 15,699 (303)

A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐07261271 in healthy participants

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan   +11 more
wiley   +1 more source

Evaluation performance of linear quadratic regulator and linear quadratic gaussian controllers on quadrotor platform

open access: yes, 2018
The purpose of this article is to evaluate the performances of the three different controllers such as Linear Quadratic Regulator (LQR), 1 DOF (Degree of Freedom) Linear Quadratic Gaussian (LQG) and 2 DOF LQG based on Quadrotor trajectory tracking and ...
Sulaeman, Erwin   +3 more
core  

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

open access: yesBiopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula   +4 more
wiley   +1 more source

Designing the MyoFusion Media: A Serum‐Free Medium Optimized for Bovine Satellite Cell Differentiation

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Cultivated meat production requires efficient differentiation of muscle progenitor cells into myotubes without relying on animal‐derived serum, which poses ethical and scalability challenges. This study aimed to develop a chemically defined, serum‐free medium optimized for bovine satellite cell differentiation.
Aysenaz Tavsanli   +3 more
wiley   +1 more source

A New LQR Optimal Control for a Single-Link Flexible Joint Robot Manipulator Based on Grey Wolf Optimizer

open access: yesMajlesi Journal of Electrical Engineering
Flexible manipulators are very commonly used in industries. In this paper a single-link flexible joint robot is modeled firstly by using Euler–Lagrange energy equation.
Navid Razmjooy   +2 more
doaj  

Eudragit®‐engineered pH‐responsive probiotic microspheres with enhanced gastrointestinal resistance and prolonged storage stability for inflammatory bowel disease therapy

open access: yesBMEMat, EarlyView.
This study reports the development of AMS@Eud core‐shell microspheres, combining calcium alginate and pH‐responsive Eudragit® L100, which exhibit exceptional gastrointestinal resistance and long‐term storage stability (only 5.28%–9.09% viability loss over 35 days at 4–25°C), and effectively alleviate inflammatory bowel disease via gut microbiota ...
Ming Teng   +5 more
wiley   +1 more source

Paradigm shift in wearable bioelectronics: Drift‐free organic field‐effect transistor biosensors enabled by diode‐connected pairs

open access: yesBMEMat, EarlyView.
Organic field‐effect transistor (OFET)‐based biosensors are promising for wearable technology due to their flexibility and low cost, but their susceptibility to signal drift from mechanical stress and environmental factors remains a challenge. Here, we highlight a novel strategy that eliminates these drifts through a fundamental redesign of the OFET ...
Yan Xu, Bin Yao, Jiahe Wang, Yichun Ding
wiley   +1 more source

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