Results 91 to 100 of about 199,141 (285)

A New Linear Inductive Voltage Adder Driver for the Saturn Accelerator

, 2000
Saturn is a dual-purpose accelerator. It can be operated as a large-area flash x-ray source for simulation testing or as a Z-pinch driver especially for K-line x-ray production. In the first mode, the accelerator is fitted with three concentric-ring 2-MV
Long, F. W., Mazarakis, M. G., Spielman, R. B., Struve, K. W.   +3 more
core   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Monte carlo investigation of photon beam characteristics and its variation with incident electron beam parameters for indigenous medical linear accelerator

Journal of Medical Physics, 2018
Purpose: A Monte Carlo model of a 6 MV medical linear accelerator (linac) unit built indigenously was developed using the BEAMnrc user code of the EGSnrc code system. The model was benchmarked against the measurements.
Subhalaxmi Mishra, P K Dixit, T Palani Selvam, Sanket S Yavalkar, D D Deshpande   +4 more
doaj   +1 more source

Comparison of Compression Schemes for CLARA

, 2012
CLARA (Compact Linear Advanced Research Accelerator)at Daresbury Laboratory is proposed to be the UK's national FEL test facility. The accelerator will be a ~250 MeV electron linac capable of producing short, high brightness electron bunches. The machine
Jones, James K., McKenzie, Julian W., Williams, Peter H.   +2 more
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Linear Accelerator Test Facility at LNF Conceptual Design Report

, 2016
Test beam and irradiation facilities are the key enabling infrastructures for research in high energy physics (HEP) and astro-particles. In the last 11 years the Beam-Test Facility (BTF) of the DA{\Phi}NE accelerator complex in the Frascati laboratory ...
Belli, Maurizio, Bolli, Bruno, Buonomo, Bruno, Cantarella, Sergio, Ceccarelli, Riccardo, Cecchinelli, Alberto, Cerafogli, Oreste, Clementi, Renato, Di Giulio, Claudio, Esposito, Adolfo, Foggetta, Luca, Frasciello, Oscar, Ghigo, Andrea, Incremona, Simona, Iungo, Franco, Martelli, Stefano, Mascio, Roberto, Piermarini, Graziano, Ricci, Ruggero, Rossi, Luis Antonio, Rotundo, Ugo, Sabbatini, Lucia, Sardone, Franco, Sensolini, Giancarlo, Stella, Angelo, Strabioli, Serena, Valente, Paolo, Zarlenga, Raffaele   +27 more
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Resonance crossing and dynamic aperture in nonscaling fixed field alternating gradient accelerators

Physical Review Special Topics. Accelerators and Beams, 2008
Operation with natural chromaticity in a linear nonscaling fixed field alternating gradient (FFAG) accelerator causes crossing of the low order resonances such as integer and half-integer.
Shinji Machida
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source