Results 101 to 110 of about 3,120,215 (305)

Vibration isolation measures due to the high sensitive linear accelerator at the Paul Scherrer Institute

MATEC Web of Conferences, 2015
The new 735m long linear accelerator “SwissFEL” at the Paul Scherrer Institute (PSI) in Würenlingen is extremely sensitive against vibrations coming from surrounding equipment (pumps, ventilators, transformers, etc.).
Trombik Peter, Fleischer Pascal, Vassiliou Michalis F.   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Low-level RF signal processing for the Next Linear Collider Test Accelerator [PDF]

, 1997
In the X-band accelerator system for the Next Linear Collider Test Accelerator (NLCTA), the Low Level RF (LLRF) drive system must be very phase stable, but concurrently, be very phase agile.
Adolphsen, C., Holmes, S., Ziomek, C.
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Proposal of the Next Incarnation of Accelerator Test Facility at KEK for the International Linear Collider [PDF]

, 2005
To reach design luminosity, the International Linear Collider (ILC) must be able to create and reliably maintain nanometer size beams. The ATF damping ring is the unique facility where ILC emittances are possible.
Vogel, V., Naito, T., Yamaoka, H., Kume, T., Kuriki, M., Kanazawa, K., Terunuma, N., Kuroda, S., Tauchi, T., Araki, S., Higashi, Y., Toge, N., Honda, Y., Kubo, K., Yokoya, K., Urakawa, J., Sugahara, R., /KEK, Tsukuba /Beijing, Inst. High Energy Phys. /Novosibirsk, IYF /Daresbury /CERN /Hiroshima U. /Orsay, LAL /LLNL, Livermore /North Carolina A-T State U. /Oxford U. /Pohang Accelerator Lab. /Queen Mary, U. of London /Royal Holloway, U. of London /DESY /SLAC /University Coll. London /Oregon U. /Tokyo U., Hayano, H., Okugi, T., Masuzawa, M., Takahashi, T.   +21 more
core  

An Alvarez-Type Linac Configuration for Future Carbon and Helium Ion Therapy Facilities with Parallel Radioisotope Production

Instruments
The increasing demand for ion beams heavier than protons—particularly carbon and helium ions—for cancer therapy has driven the development of advanced accelerator technologies.
Lazar Nikitovic, Maurizio Vretenar, Toms Torims   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source