Results 121 to 130 of about 3,120,215 (305)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Enabling Technologies for Petascale Electromagnetic Accelerator Simulation [PDF]

, 2007
The SciDAC2 accelerator project at SLAC aims to simulate an entire three-cryomodule radio frequency (RF) unit of the International Linear Collider (ILC) main Linac.
Akcelik, Volkan, Shephard, Mark, Lee, Lie-Quan, Schussman, Greg, Luo, Xiaojun, Chen, Sheng, Ko, Kwok, Ge, Li-Xin, Ng, Cho, Prudencio, Ernesto, Uplenchwar, Ravi   +10 more
core  

Research and Development of High Power Klystron for C-band Industrial Linear Accelerator

Yuanzineng kexue jishu
In order to meet the power source requirements of C-band linear accelerators for industrial applications, a C-band high power klystron operating at a frequency of 5 712 MHz was developed.
YANG Yu,  YANG Jinghe,  WANG Changqiang,  LIU Xiuying,  HAN Guangwen,  WU Qingfeng,  FAN Yuxuan,  WANG Bo,  LEI Han,  BI Zhenliang,  CHEN Wei,  CUI Aijun,  YU Guolong,  LYU Yuepeng,  WANG Guobao,  ZHANG Lifeng,  ZHU Zhibin
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Beamstrahlung spectra in next generation linear colliders

, 1992
For the next generation of linear colliders, the energy loss due to beamstrahlung during the collision of the e{sup +}e{sup {minus}} beams is expected to substantially influence the effective center-of-mass energy distribution of the colliding particles.
Chen, P. (Stanford Linear Accelerator Center, Menlo Park, CA (United States)), Barklow, T., Kozanecki, W. (DAPNIA-SPP, CEN-Saclay (France))   +2 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A history of thyratron lifetimes at the Stanford Linear Accelerator Center [PDF]

, 1994
The Stanford Linear Accelerator Center (SLAC) has been in almost continuous operation since the middle 1960s, providing a remarkable opportunity to amass thyratron data.
Ficklin, D B, Ficklin, D. B. Jr.
core  

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

High gradient tests of SLAC Linear Collider Accelerator Structures [PDF]

, 1994
This paper describes the current SLAC R&D program to develop room temperature accelerator structures for the Next Linear Collider (NLC). The structures are designed to operate at 11.4 GHz at an accelerating gradient in the range of 50 to 100 MV/m. In the
Lavine, T., Menegat, L., Koontz, R. F., Eichner, J., Hoag, H. A., Loewen, R., Deruyter, H., Wang, J. W., Fant, K. H., Loew, G. A.   +9 more
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source