Results 41 to 50 of about 3,120,215 (305)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reluctance Accelerator Efficiency Optimization via Pulse Shaping [PDF]

open access: yes, 2014
Reluctance accelerators are used to apply linear forces to ferromagnetic projectiles via solenoids. Ef ciency increases for a single-stage reluctance accelerator were produced by manipulating the input current pulse supplied by a discharging capacitor ...
Bristoll, BT   +3 more
core  

Improvement of PEP-II Linear Optics with a MIA-Derived Virtual Accelerator [PDF]

open access: yes, 2006
In several past studies, model independent analysis, in conjunction with a virtual accelerator model, has been successful in improving PEP-II linear geometric optics. In many cases, optics improvement yielded an increase in machine luminosity.
Cerio, B., U., /Colgate
core   +1 more source

Quartz bar Cherenkov detector characterization at the LEETECH spectrometer

open access: yesЯдерна фізика та енергетика, 2017
Results of simulation and measurements on the LEETECH facility with quartz Cherenkov detector prototype which is one of the candidates for the time-of-flight technique implementation at the upgraded BES-III and HIEPA (China) experiments are presented ...
D. Attie   +16 more
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Next Linear Collider test accelerator injector upgrade [PDF]

open access: yes, 1995
The Next Linear Collider Test Accelerator (NLCTA) being built at SLAC will integrate the new technologies of X-band Accelerator structures and RF systems for the Next Linear Collider, demonstrate multibunch beam-loading energy compensation and ...
Miller, R. H.   +3 more
core  

High gradient experiments on NLCTA accelerator structures [PDF]

open access: yes, 1996
This paper presents new results of high-gradient studies performed on a 1.8 m traveling-wave accelerator section with detuned high-order deflecting modes.
Wang, J. W., Eichner, J. P., Fant, K. H.
core   +1 more source

Linear Accelerator Simulator

open access: yesThe British Journal of Radiology, 1966
The machine shown (Fig. 1), which was manufactured by S. Van Dal & Co., of Perth, Western Australia, has a table which can only be moved through an arc of 60 deg., instead of 360 deg. as in the Christie Hospital unit (Greene, Nelson and Gibb, 1964); a later model by the same firm has overcome this limitation which in practice proves to be only a ...
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

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