Results 41 to 50 of about 199,141 (285)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Quartz bar Cherenkov detector characterization at the LEETECH spectrometer
Ядерна фізика та енергетика, 2017 Results of simulation and measurements on the LEETECH facility with quartz Cherenkov detector prototype which is one of the candidates for the time-of-flight technique implementation at the upgraded BES-III and HIEPA (China) experiments are presented ...
D. Attie +16 more
doaj
Heavy-Ion Linear Accelerator [PDF]
Review of Scientific Instruments, 1961 Two linear accelerators have been built for the acceleration of ions in the mass region from helium to argon. The linear accelerators consist of two 70-Mc cavity resonators of the Alvarez design. Ions with a charge to mass ratio e/m≥0.15 times the e/m of a proton are injected into the first cavity of the linear accelerator with a Cockcroft-Walton ...
Hubbard, E.L. +17 more
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Sensors, 2021 The low-level radio frequency (LLRF) control system is one of the fundamental parts of a particle accelerator, ensuring the stability of the electro-magnetic (EM) field inside the resonant cavities. It leverages on the precise measurement of the field by
Tomasz Kowalski +7 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Design, commissioning and first measurements at the LEETECH spectrometer
Ядерна фізика та енергетика, 2017 The LEETECH (Low Energy Electron TECHnique) electron test beam facility has been designed and manufactured at Laboratoire de l’Accelerateur Lineaire (Orsay, France). Energy of electron beam can vary from 100 keV to 5 MeV.
D. Attie +16 more
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source