Results 61 to 70 of about 199,141 (285)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Physical Review Special Topics. Accelerators and Beams, 2005 We calculate the optimum energy efficiency of a laser-driven linear accelerator by adopting a simple linear model. In the case of single bunch operation, the energy efficiency can be enhanced by incorporating the accelerator into a cavity that is pumped ...
Y. C. Neil Na, R. H. Siemann, R. L. Byer
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Research and Design of Varian Accelerator Quality Management Monitoring System Based on Log Files
Zhongguo yiliao qixie zazhiIn order to track the running status of the accelerator in real time, discover potential problems in time, reduce the failure rate, and ensure the safety of radiotherapy patients, a linear accelerator quality management monitoring system is designed ...
Jinhong YAO, Yan JIN, Xinyu ZHAO
doaj +1 more source
Enzyme intermediates captured “on the fly” by mix-and-inject serial crystallography
BMC Biology, 2018 Background Ever since the first atomic structure of an enzyme was solved, the discovery of the mechanism and dynamics of reactions catalyzed by biomolecules has been the key goal for the understanding of the molecular processes that drive life on earth ...
Jose L. Olmos +49 more
doaj +1 more source
Dosimetric characteristics of a new linear accelerator under gated operation. [PDF]
, 2006 Respiratory gated radiotherapy may allow reduction of the treatment margins, thus sparing healthy tissue and/or allowing dose escalation to the tumor. However, current commissioning and quality assurance of linear accelerators do not include evaluation ...
Kriminski, Sergey +2 more
core +1 more source
Physics Case for the International Linear Collider
, 2015 We summarize the physics case for the International Linear Collider (ILC). We review the key motivations for the ILC presented in the literature, updating the projected measurement uncertainties for the ILC experiments in accord with the expected ...
Barklow, Tim +17 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A Small Linear Accelerator for Charged Microparticles
Applied SciencesResearching cosmic dust requires terrestrial facilities for accelerating analogues of different sizes and masses. To address the area of very lightweight particles, electrostatic accelerators like Van de Graaf accelerators or Linear Accelerators (LINACs)
Marcel Bauer +7 more
doaj +1 more source