Results 61 to 70 of about 37,360 (256)

Concise review of recent advances and applications of the electron linear accelerator ELU 4 in scientific and technical fields

Physical Sciences and Technology
The analysis presented in this concise review is directed towards evaluating the contemporary trends and practical implementations of the ELU-4 electronic linear accelerator across a broad spectrum of scientific and technological domains.
Zhassulan Nakysbekov, Daniyar Ismailov, Stefano Bellucci , Timur Tukhfatullin, Oleg Bogdanov , Boris Tronin, Kundyz Turmanova, Gulnur Suyundykova, Valentina Grichshenko , Mustakhim Pshikov, Assem Alzhanova   +10 more
doaj   +1 more source

Enzyme intermediates captured “on the fly” by mix-and-inject serial crystallography

BMC Biology, 2018
Background Ever since the first atomic structure of an enzyme was solved, the discovery of the mechanism and dynamics of reactions catalyzed by biomolecules has been the key goal for the understanding of the molecular processes that drive life on earth ...
Jose L. Olmos, Suraj Pandey, Jose M. Martin-Garcia, George Calvey, Andrea Katz, Juraj Knoska, Christopher Kupitz, Mark S. Hunter, Mengning Liang, Dominik Oberthuer, Oleksandr Yefanov, Max Wiedorn, Michael Heyman, Mark Holl, Kanupriya Pande, Anton Barty, Mitchell D. Miller, Stephan Stern, Shatabdi Roy-Chowdhury, Jesse Coe, Nirupa Nagaratnam, James Zook, Jacob Verburgt, Tyler Norwood, Ishwor Poudyal, David Xu, Jason Koglin, Matthew H. Seaberg, Yun Zhao, Saša Bajt, Thomas Grant, Valerio Mariani, Garrett Nelson, Ganesh Subramanian, Euiyoung Bae, Raimund Fromme, Russell Fung, Peter Schwander, Matthias Frank, Thomas A. White, Uwe Weierstall, Nadia Zatsepin, John Spence, Petra Fromme, Henry N. Chapman, Lois Pollack, Lee Tremblay, Abbas Ourmazd, George N. Phillips, Marius Schmidt   +49 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Estimation of Primary Electron Beam Parameters of Individual Linear Accelerator Using Monte Carlo Method

Zhongguo yiliao qixie zazhi
ObjectiveTo estimate the primary electron beam parameters (PEB), including energy, radial intensity distribution and average angular divergence, of the individual linear accelerator using the Monte Carlo method. MethodsA model of the treatment head and a
Yisong HE, Hang YU, Yuchuan FU, Jinyou HU, Lian ZOU   +4 more
doaj   +1 more source

Vibration isolation measures due to the high sensitive linear accelerator at the Paul Scherrer Institute

MATEC Web of Conferences, 2015
The new 735m long linear accelerator “SwissFEL” at the Paul Scherrer Institute (PSI) in Würenlingen is extremely sensitive against vibrations coming from surrounding equipment (pumps, ventilators, transformers, etc.).
Trombik Peter, Fleischer Pascal, Vassiliou Michalis F.   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Determining X-Ray Effective Energy in Linear Accelerator (LINAC) Radiotherapy Instrument

Jurnal Ilmiah Pendidikan Fisika Al-Biruni, 2018
This research in determining x-ray effective energy in linear accelerator (Linac) radiotherapy device was done using copper plates at different thicknesses by determining the Half Value Layer (HVL) for each energy. The purpose of this research is to know
Fauziah Fauziah, Bualkar Abdullah
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Research and design of high-reliability magnet power supply architecture for CiADS

Nuclear Engineering and Technology
The China Initiative Accelerator Driven System (CiADS) is a major national scientific infrastructure project managed by the Institute of Modern Physics, Chinese Academy of Sciences.
Wenqi Lyu, Yuan He, Ximeng Chen, Zhongzu Zhou, Zhijun Wang, Jiang Zhao   +5 more
doaj   +1 more source

4π radiotherapy using a linear accelerator: A misnomer in violation of the solid geometric boundary conditions in three-dimensional Euclidean space

Journal of Medical Physics, 2019
Purpose: The concept of 4πc radiotherapy is a radiotherapy planning technique receiving much attention in recent times. The aim of this article is to disprove the feasibility of the 4π radiotherapy using a cantilever-type linear accelerator or any other ...
Biplab Sarkar, Tharmarnadar Ganesh, Anusheel Munshi, Arjunan Manikandan, Bidhu Kalyan Mohanti   +4 more
doaj   +1 more source