Results 51 to 60 of about 37,360 (256)

Energy efficiency of an intracavity coupled, laser-driven linear accelerator pumped by an external laser

Physical Review Special Topics. Accelerators and Beams, 2005
We calculate the optimum energy efficiency of a laser-driven linear accelerator by adopting a simple linear model. In the case of single bunch operation, the energy efficiency can be enhanced by incorporating the accelerator into a cavity that is pumped ...
Y. C. Neil Na, R. H. Siemann, R. L. Byer
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Research and Design of Varian Accelerator Quality Management Monitoring System Based on Log Files

Zhongguo yiliao qixie zazhi
In order to track the running status of the accelerator in real time, discover potential problems in time, reduce the failure rate, and ensure the safety of radiotherapy patients, a linear accelerator quality management monitoring system is designed ...
Jinhong YAO, Yan JIN, Xinyu ZHAO
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Small Linear Accelerator for Charged Microparticles

Applied Sciences
Researching cosmic dust requires terrestrial facilities for accelerating analogues of different sizes and masses. To address the area of very lightweight particles, electrostatic accelerators like Van de Graaf accelerators or Linear Accelerators (LINACs)
Marcel Bauer, Yanwei Li, Ralf Srama, Florian Behrens, Anna Mocker, Felix Schäfer, Jonas Simolka, Heiko Strack   +7 more
doaj   +1 more source

Ocular Complications of Radiotherapy for Head and Neck Tumours

Delhi Journal of Ophthalmology, 2019
Aim: To study the various ocular complications associated with radiotherapy and correlate them with duration & dose of radiation. Design: Hospital based prospective study Methods: The present study comprises of 100 patients of head and neck tumors who ...
Sarita Maharia, Kalpna Jain, H. S. Kumar
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Ion-hose instability in a long-pulse linear induction accelerator

Physical Review Special Topics. Accelerators and Beams, 2003
The ion-hose instability is a transverse electrostatic instability which occurs on electron beams in the presence of a low-density ion channel. It is a phenomenon quite similar to the interaction between electron clouds and proton or positron beams in ...
Thomas C. Genoni, Thomas P. Hughes
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source