Results 51 to 60 of about 3,120,215 (305)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The electronics and data acquisition system for the Wire Imaging Synchrotron Radiation Detector at the SLC (Stanford Linear Collider) [PDF]

, 1990
The Stanford Linear Collider (SLC) located at the Stanford Linear Accelerator Center collides electrons and positrons produced in the linear accelerator pulse by pulse. We determine the energy of each beam by measuring the angle of deflection of the beam
Briggs, D.D. (Stanford Linear Accelerator Center, Menlo Park, CA (USA)), Gomez, J.J., Kent, J. (California Univ., Santa Cruz, CA (USA)), Rouse, F., Von Zanthier, C.   +4 more
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Design, commissioning and first measurements at the LEETECH spectrometer

Ядерна фізика та енергетика, 2017
The LEETECH (Low Energy Electron TECHnique) electron test beam facility has been designed and manufactured at Laboratoire de l’Accelerateur Lineaire (Orsay, France). Energy of electron beam can vary from 100 keV to 5 MeV.
D. Attie, S. Barsuk, O. Bezshyyko, L. Burmistrov, A. Chaus, P. Colas, O. Fedorchuk, L. Golinka-Bezshyyko, I. Kadenko, V. Krylov, V. Kubytskyi, R. Lopez, H. Monard, V. Rodin, M. Titov, D. Tomassini, A. Variola   +16 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Advanced Virtual Accelerator Software: A linear accelerator simulation code

Physical Review Accelerators and Beams
The Advanced Virtual Accelerator Software (avas) has been developed to simulate beam transport processes in high-intensity linear accelerators and has been used in the China Initiative Accelerator Driven System (CiADS) project.
Chao Jin, Zhijun Wang, Xin Qi, Yuan He, Zhongyi Li, Kunxiang Sun, Xiaolong Chen, Chi Feng, Xiaoying Zhao, Yaxin Hu, Yuan Tian, Kai Li   +11 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Intrabeam scattering formulas for high energy beams

Physical Review Special Topics. Accelerators and Beams, 2005
We derive completely integrated formulas for emittance growth times due to intrabeam scattering for charged particle beams in the high energy limit, including the effect of lattice parameters that vary around the accelerator ring.
Kiyoshi Kubo, Sekazi K. Mtingwa, Andrzej Wolski   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Energy recovery proton linear accelerator

Physical Review Accelerators and Beams
High-power proton linear accelerators have important applications in both scientific research and industry. However, the operation of such accelerators with megawatt-level beam power is expensive and limits the broad availability of these facilities.
Ji Qiang
doaj   +1 more source