Results 51 to 60 of about 5,040,500 (260)

Commissioning an Elekta Versa HD linear accelerator

Journal of Applied Clinical Medical Physics, 2016
The purpose of this study is to report the dosimetric aspects of commissioning performed on an Elekta Versa HD linear accelerator (linac) with high‐dose‐rate flattening filter‐free (FFF) photon modes and electron modes.
G. Narayanasamy, D. Saenz, W. Cruz, C. Ha, N. Papanikolaou, S. Stathakis   +5 more
semanticscholar   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Simultaneous operation of two soft x-ray free-electron lasers driven by one linear accelerator

New Journal of Physics, 2016
Extreme-ultraviolet to x-ray free-electron lasers (FELs) in operation for scientific applications are up to now single-user facilities. While most FELs generate around 100 photon pulses per second, FLASH at DESY can deliver almost two orders of magnitude
B. Faatz, E. Plönjes, S. Ackermann, A. Agababyan, V. Asgekar, V. Ayvazyan, S. Baark, N. Baboi, V. Balandin, N. Bargen, Y. Bican, O. Bilani, J. Bödewadt, M. Böhnert, R. Böspflug, S. Bonfigt, H. Bolz, F. Borges, O. Borkenhagen, M. Brachmanski, M. Braune, A. Brinkmann, O. Brovko, T. Bruns, P. Castro, J. Chen, M. Czwalinna, H. Damker, W. Decking, M. Degenhardt, A. Delfs, T. Delfs, H. Deng, M. Dressel, H. Duhme, S. Düsterer, H. Eckoldt, A. Eislage, M. Felber, J. Feldhaus, P. Geßler, M. Gibau, N. Golubeva, T. Golz, J. Gonschior, A. Grebentsov, M. Grecki, C. Grün, S. Grunewald, K. Hacker, L. Hänisch, A. Hage, T. Hans, E. Hass, A. Hauberg, O. Hensler, M. Hesse, K. Heuck, A. Hidvégi, M. Holz, K. Honkavaara, H. Höppner, A. Ignatenko, J. Jäger, U. Jastrow, R. Kammering, S. Karstensen, A. Kaukher, H. Kay, B. Keil, K. Klose, V. Kocharyan, M. Köpke, M. Körfer, W. Kook, B. Krause, O. Krebs, S. Kreis, F. Krivan, J. Kuhlmann, M. Kuhlmann, G. Kube, T. Laarmann, C. Lechner, S. Lederer, A. Leuschner, D. Liebertz, J. Liebing, A. Liedtke, L. Lilje, T. Limberg, D. Lipka, B. Liu, B. Lorbeer, K. Ludwig, H. Mahn, G. Marinkovic, C. Martens, F. Marutzky, M. Maslocv, D. Meissner, N. Mildner, V. Miltchev, S. Molnar, D. Mross, F. Müller, R. Neumann, P. Neumann, D. Nölle, F. Obier, M. Pelzer, H. Peters, K. Petersen, A. Petrosyan, G. Petrosyan, L. Petrosyan, V. Petrosyan, A. Petrov, S. Pfeiffer, A. Piotrowski, Z. Pisarov, T. Plath, P. Pototzki, M. Prandolini, J. Prenting, G. Priebe, B. Racky, T. Ramm, K. Rehlich, R. Riedel, M. Roggli, M. Röhling, J. Rönsch-Schulenburg, J. Rossbach, V. Rybnikov, J. Schäfer, J. Schaffran, H. Schlarb, G. Schlesselmann, M. Schlösser, P. Schmid, C. Schmidt, F. Schmidt-Föhre, M. Schmitz, E. Schneidmiller, A. Schöps, M. Scholz, S. Schreiber, K. Schütt, U. Schütz, H. Schulte-schrepping, M. Schulz, A. Shabunov, P. Smirnov, E. Sombrowski, A. Sorokin, B. Sparr, J. Spengler, M. Staack, M. Stadler, C. Stechmann, Bernd Steffen, N. Stojanović, V. Sychev, E. Syresin, T. Tanikawa, F. Tavella, N. Tesch, K. Tiedtke, M. Tischer, R. Treusch, S. Tripathi, P. Vagin, P. Vetrov, S. Vilcins, M. Vogt, A. Wagner, T. Wamsat, H. Weddig, G. Weichert, H. Weigelt, N. Wentowski, C. Wiebers, T. Wilksen, A. Willner, K. Wittenburg, T. Wohlenberg, J. Wortmann, W. Wurth, M. Yurkov, I. Zagorodnov, J. Zemella   +191 more
semanticscholar   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Some aspects of superconducting accelerator design [PDF]

, 1982
The performance of an accelerator can be characterized by the efficiency with which electrical energy, the minimumm energy needed to generate a given beam voltage. The current accelerator improvement program at SLAC aims at raising the beam voltage to 50
St. Lorant, S. J., Farkas, Z. D., Z.D. Farkas, S.J. St. Lorant   +3 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Reluctance Accelerator Efficiency Optimization via Pulse Shaping

, 2014
Reluctance accelerators are used to apply linear forces to ferromagnetic projectiles via solenoids. Ef ciency increases for a single-stage reluctance accelerator were produced by manipulating the input current pulse supplied by a discharging capacitor ...
Bristoll, BT, Bartlett, PA, Cooper, LM, Van Cleef, AR   +3 more
core  

R&D of Accelerator Structures at SLAC [PDF]

, 2007
The research activities for accelerator structures at SLAC are reviewed including the achievement via the main linac design for the Next Linear Collider (NLC), the program adjustment after the decision of the International Linear Collider (ILC) to be ...
Wang, J.W.
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Opportunistic or event-driven maintenance at the Stanford Linear Accelerator Center [PDF]

, 1997
The Stanford Linear Accelerator Center (SLAC) uses a maintenance management philosophy that is best described as opportunistic or event-driven. Opportunistic maintenance can be defined as a systematic method of collecting, investigating, pre-planning ...
Sheppard, J.C., Anderson, S., Allen, C W, Anderson, S, Erickson, R, Linebarger, W A, Allen, C.W., Erickson, R., Stanek, M., Linebarger, W., Sheppard, J C, Stanek, M   +11 more
core