Results 41 to 50 of about 54,935 (211)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Affine connections generated by absolutely parallel vector and convector fields
Дифференциальная геометрия многообразий фигур, 2018 Affine connections are considered both on an n-dimensional manifold and in the linear fibre bundle over the manifold. The expressions for the flat connection object in the terms of coordinates of absolutely parallel n vectors (covektors) and their ...
K. Polyakova
doaj
Equivariant bifurcation in geometric variational problems
, 2013 We prove an extension of a celebrated equivariant bifurcation result of J. Smoller and A. Wasserman, in an abstract framework for geometric variational problems.
Bettiol, Renato G. +2 more
core +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Six results on Painleve VI [PDF]
, 2005 After recalling some of the geometry of the sixth Painleve equation, we will describe how the Okamoto symmetries arise naturally from symmetries of Schlesinger's equations and summarise the classification of the Platonic Painleve six solutions.
Boalch, Philip
core
On the Geodesic Form of Non-Relativistic Dynamic Equations
, 1999 It is shown that any second order dynamic equation on a configuration bundle $Q\to R$ of non-relativistic mechanics is equivalent to a geodesic equation with respect to a (non-linear) connection on the tangent bundle $TQ\to Q$.
Mangiarotti, L., Sardanashvily, G.
core +2 more sources
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Solving the Ward Identities of Irrational Conformal Field Theory
, 1993 The affine-Virasoro Ward identities are a system of non-linear differential equations which describe the correlators of all affine-Virasoro constructions, including rational and irrational conformal field theory.
Halpern, M. B., Obers, N. A.
core +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source