Results 61 to 70 of about 7,284 (228)

Output feedback design and controllable cascade connections of nonlinear systems

open access: yes, 1982
For linear control systems necessary and sufficient conditions have been established for transforming a linear multiinput multioutput controllable system to a single input controllable system by use of linear output feedback. This problem is studied here
Tsinias, J.   +2 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Left-Invariant Affine Structures on Reductive Lie Groups [PDF]

open access: yes, 1996
We describe left-invariant affine structures (that is, left-invariant flat torsion-free affine connections ∇) on reductive linear Lie groupsG. They correspond bijectively to LSA-structures on the Lie algebra g ofG.
Dietrich Burde, Burde, Dietrich
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Metrization problem for linear connections and holonomy algebras [PDF]

open access: yes, 2008
summary:We contribute to the following: given a manifold endowed with a linear connection, decide whether the connection arises from some metric tensor. Compatibility condition for a metric is given by a system of ordinary differential equations. Our aim
Vanžurová, Alena
core   +1 more source

Affine transformations of the tangent bundle with a complete lift connection over a manifold with a linear connection of special type

open access: yesДифференциальная геометрия многообразий фигур, 2018
In this paper we obtain exact upper bounds for the dimensions of Lie al­ge­bras of infinitesimal affine transformations in tangent bundles with a comp­lete lift connection in the case when the base space is a manifold equipped with a non-projective Euclidean linear connection of a special type.
A. Sultanov, G. Sultanova
openaire   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Algebraic theory of affine monoids

open access: yes, 2013
This thesis treats several aspects of affine monoids. First, we consider the structure of the set of holes of an affine monoid Q. This set is the difference between Q and its normalization.
Welker, Volkmar (Prof. Dr.)   +1 more
core   +1 more source

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