Results 91 to 100 of about 3,658,908 (303)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Approximation of Bayesian inverse problems for PDEs [PDF]
, 2010 Inverse problems are often ill posed, with solutions that depend sensitively on data. In any numerical approach to the solution of such problems, regularization of some form is needed to counteract the resulting instability.
Dashti, Massoumeh +7 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An algorithm for distributed parameter estimation in modal regression models
Statistical Theory and Related FieldsIn this paper, we propose a new algorithm to handle massive data sets, which are modelled by modal regression models. Differing from the existing methods regarding distributed modal regression, the proposed method combines the divide-and-conquer idea and
Xuejun Ma, Xiaochao Xia
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
An L1 estimation algorithm with degeneracy and linear constraints [PDF]
, 2002 An implementation of the reduced gradient algorithm is proposed to solve the linear L1 estimation problem (least absolute deviations regression) with linear equality or inequality constraints, including rank deficient and degenerate cases.
Shi, M., Lukas, M.A.
core
Research on linear approximations of simplified Trivium
Tongxin xuebao, 2016 The linear approximations of simplified Trivium with the initialization of 288 clocks(2-round Trivium) was studied.An algorithm was designed to search optimal linear approximations.Moreover,a method was presented to conduct a linear approximation of 2 ...
Meng MA, Ya-qun ZHAO
doaj
Generalized quasi-linear approximation and non-normality in Taylor-Couette spiral turbulence. [PDF]
Philos Trans A Math Phys Eng Sci, 2023 Oishi JS, Baxter M.
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source